Department of Child Health, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Am J Respir Crit Care Med. 2010 May 1;181(9):969-74. doi: 10.1164/rccm.200906-0897OC. Epub 2010 Jan 21.
Few studies have investigated childhood respiratory outcomes of intrauterine growth retardation (IUGR), and it is unclear if catch-up growth in these children influences lung function.
We determined if lung function differed in 8- to 9-year-old children born at term with or without growth retardation, and, in the growth-retarded group, if lung function differed between those who did and those who did not show weight catch up.
Caucasian singleton births of 37 weeks or longer gestation from the Avon Longitudinal Study of Parents and Children (n = 14,062) who had lung spirometry at 8-9 years of age were included (n = 5,770).
Infants with gestation-appropriate birthweight (n = 3,462) had significantly better lung function at 8-9 years of age than those with IUGR (i.e., birthweight <10th centile [n = 576] [SD differences and confidence intervals adjusted for sex, gestation, maternal smoking during pregnancy, and social class: FEV(1), -0.198 (-0.294 to -0.102), FVC, -0.131 (-0.227 to -0.036), forced midexpiratory flow between 25 and 75% of vital capacity -0.149 (-0.246 to -0.053)]). Both groups had similar respiratory symptoms. All spirometry measurements were higher in children with IUGR who had weight catch-up growth (n = 430) than in those without (n = 146), although the differences were not statistically significant. Both groups remained significantly lower than control subjects. Growth-retarded asymmetric and symmetric children had similar lung function.
IUGR is associated with poorer lung function at 8-9 years of age compared with control children. Although the differences were not statistically significant, spirometry was higher in children who showed weight catch-up growth, but remained significantly lower than the control children.
很少有研究调查宫内生长迟缓（IUGR）对儿童呼吸系统的影响，也不清楚这些儿童的追赶生长是否会影响肺功能。
我们旨在确定在 8-9 岁足月出生且无生长迟缓的儿童中，肺功能是否存在差异，以及在生长迟缓的儿童中，体重是否有追赶生长的儿童与没有体重追赶生长的儿童之间，肺功能是否存在差异。
纳入来自英国阿冯纵向研究父母和儿童（n = 14062）的 37 周或以上胎龄的白人单胎分娩，且 8-9 岁时进行了肺肺活量测定（n = 5770）。
具有胎龄适当出生体重（n = 3462）的婴儿在 8-9 岁时的肺功能明显好于 IUGR 婴儿（即出生体重<第 10 百分位数[n = 576] [经性别、胎龄、母亲孕期吸烟以及社会阶层调整的差异和置信区间：FEV1，-0.198（-0.294 至-0.102），FVC，-0.131（-0.227 至-0.036），用力呼出量 25%至 75%肺活量之间的中间流量-0.149（-0.246 至-0.053）]）。两组均有类似的呼吸道症状。在有体重追赶生长（n = 430）的 IUGR 儿童中，所有肺活量测量值均高于无体重追赶生长（n = 146）的儿童，但差异无统计学意义。两组均明显低于对照组。生长迟缓的不对称和对称儿童的肺功能相似。
与对照组儿童相比，IUGR 儿童在 8-9 岁时肺功能较差。虽然差异无统计学意义，但有体重追赶生长的儿童的肺活量较高，但仍明显低于对照组儿童。
