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牛乳及乳制品中具有阿片样活性的一种物质。

A material with opioid activity in bovine milk and milk products.

作者信息

Brantl V, Teschemacher H

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1979 Apr;306(3):301-4. doi: 10.1007/BF00507118.

DOI:10.1007/BF00507118
PMID:471082
Abstract

Chloroform-methanol extracts of lyophilized milk, of commercially available dried milk or baby food and of casein digests were tested for opioid activity on the guinea-pig ileum longitudinal muscle-myenteric plexus preparation. Compounds with opioid activity--which proved to be resistant to peptidases--were detected in certain batches of baby food, casein digest, and cow milk in considerably varying amounts.

摘要

对冻干牛奶、市售奶粉或婴儿食品以及酪蛋白消化物的氯仿 - 甲醇提取物进行了测试,以检测其对豚鼠回肠纵肌 - 肠肌丛标本的阿片样物质活性。在某些批次的婴儿食品、酪蛋白消化物和牛奶中检测到了具有阿片样物质活性的化合物——这些化合物被证明对肽酶具有抗性,且含量差异很大。

相似文献

1
A material with opioid activity in bovine milk and milk products.牛乳及乳制品中具有阿片样活性的一种物质。
Naunyn Schmiedebergs Arch Pharmacol. 1979 Apr;306(3):301-4. doi: 10.1007/BF00507118.
2
Novel opioid peptides derived from casein (beta-casomorphins). I. Isolation from bovine casein peptone.源自酪蛋白的新型阿片肽(β-酪蛋白吗啡样肽)。I. 从牛乳酪蛋白胨中分离。
Hoppe Seylers Z Physiol Chem. 1979 Sep;360(9):1211-6. doi: 10.1515/bchm2.1979.360.2.1211.
3
Opioid antagonist peptides derived from kappa-casein.
J Dairy Res. 1989;56(3):363-6. doi: 10.1017/s0022029900028818.
4
Opioid activities of human beta-casomorphins.人β-酪蛋白水解产物的阿片样活性。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Dec;331(4):351-4. doi: 10.1007/BF00500818.
5
Determination of alkaline phosphatase in casein: collaborative study.
J Assoc Off Anal Chem. 1981 May;64(3):623-7.
6
Infrared milk analyzer.红外牛奶分析仪
J Dairy Sci. 1972 May;55(5):650-1. doi: 10.3168/jds.S0022-0302(72)85554-1.
7
Improved method for the simultaneous determination of whey proteins, caseins and para-kappa-casein in milk and dairy products by capillary electrophoresis.毛细管电泳法同时测定牛奶及乳制品中乳清蛋白、酪蛋白和对κ-酪蛋白的改进方法
J Chromatogr A. 2001 Apr 27;915(1-2):225-30. doi: 10.1016/s0021-9673(01)00617-3.
8
Demonstration of beta-casomorphin immunoreactive materials in in vitro digests of bovine milk and in small intestine contents after bovine milk ingestion in adult humans.
Peptides. 1985 Sep-Oct;6(5):825-30. doi: 10.1016/0196-9781(85)90308-0.
9
[Change in the protein components of milk during the preparation of a sour milk product with an increased biological value and biolact].
Zdravookhr Kirg. 1978 May-Jun(3):12-4.
10
Tissue content of opioid peptides in the myenteric plexus-longitudinal muscle of guinea-pig small intestine.豚鼠小肠肌间神经丛-纵行肌中阿片肽的组织含量
J Neurochem. 1988 Jul;51(1):32-7. doi: 10.1111/j.1471-4159.1988.tb04831.x.

引用本文的文献

1
Effects of A1 Milk, A2 Milk and the Opioid-like Peptide β-Casomorphin-7 on the Proliferation of Human Peripheral Blood Mononuclear Cells.A1 牛奶、A2 牛奶和阿片样肽 β-酪啡肽-7 对人外周血单个核细胞增殖的影响。
Biomolecules. 2024 Jun 13;14(6):690. doi: 10.3390/biom14060690.
2
Contributions of the International Narcotics Research Conference to Opioid Research Over the Past 50 years.过去50年国际麻醉品研究会议对阿片类药物研究的贡献。
Adv Drug Alcohol Res. 2022 Feb 18;2:10115. doi: 10.3389/adar.2022.10115. eCollection 2022.
3
Food-Derived Opioid Peptides in Human Health: A Review.

本文引用的文献

1
The effects of adrenaline, noradrenaline and isoprenaline on inhibitory alpha- and beta-adrenoceptors in the longitudinal muscle of the guinea-pig ileum.肾上腺素、去甲肾上腺素和异丙肾上腺素对豚鼠回肠纵肌中抑制性α和β肾上腺素能受体的作用。
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2
Inactivity of narcotic glucuronides as analgesics and on guinea-pig ileum.麻醉性葡萄糖醛酸苷作为镇痛药及对豚鼠回肠的无活性。
J Pharmacol Exp Ther. 1972 Nov;183(2):404-10.
3
Opiate receptor: demonstration in nervous tissue.阿片受体:在神经组织中的显示
食物来源的阿片肽在人类健康中的作用:综述。
Int J Mol Sci. 2020 Nov 21;21(22):8825. doi: 10.3390/ijms21228825.
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Systematic Review of the Gastrointestinal Effects of A1 Compared with A2 β-Casein.A1 与 A2 β-酪蛋白的胃肠道影响的系统评价。
Adv Nutr. 2017 Sep 15;8(5):739-748. doi: 10.3945/an.116.013953. Print 2017 Sep.
5
Modulation of post-prandial insulin release by ingested opiate-like substances in dogs.摄入类阿片物质对犬餐后胰岛素释放的调节作用。
Diabetologia. 1983 Feb;24(2):113-6. doi: 10.1007/BF00297392.
6
Demonstration of specific receptors for fluoresceinated casein on human neutrophils and monocytes using flow cytometry.利用流式细胞术证实人中性粒细胞和单核细胞上存在荧光素化酪蛋白的特异性受体。
Inflammation. 1983 Dec;7(4):363-75. doi: 10.1007/BF00916301.
Science. 1973 Mar 9;179(4077):1011-4. doi: 10.1126/science.179.4077.1011.
4
Isolation of a novel endogenous opiate analgesic from human blood.从人血中分离出一种新型内源性阿片类镇痛药。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2226-30. doi: 10.1073/pnas.73.7.2226.
5
Antibodies as a means of isolating and characterizing biologically active substances: presence of a non-peptide, morphine-like compound in the central nervous system.抗体作为分离和鉴定生物活性物质的手段:中枢神经系统中存在一种非肽类、吗啡样化合物。
Proc Natl Acad Sci U S A. 1976 Jun;73(6):2132-6. doi: 10.1073/pnas.73.6.2132.
6
Radioimmunoassay of beta-endorphin basal and stimulated levels in extracted rat plasma.大鼠血浆提取物中β-内啡肽基础水平和刺激水平的放射免疫测定。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Jun;303(2):171-4. doi: 10.1007/BF00508064.
7
Characterization of opiate-like materials in blood and urine.血液和尿液中类阿片物质的特性分析。
Adv Biochem Psychopharmacol. 1978;18:313-9.
8
An inhibitor of opiate receptor binding from human erythrocytes identified as a glutathione-copper complex.一种从人红细胞中鉴定出的阿片受体结合抑制剂,为谷胱甘肽-铜复合物。
Life Sci. 1977 Dec 1;21(11):1559-67. doi: 10.1016/0024-3205(77)90232-6.
9
Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.内源性非肽类吗啡样化合物与阿片受体的结合。
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4927-31. doi: 10.1073/pnas.74.11.4927.
10
Detection of a long acting endogenous opioid in blood and small intestine.血液和小肠中长效内源性阿片样物质的检测。
Life Sci. 1977 Jul 1;21(1):105-16. doi: 10.1016/0024-3205(77)90430-1.