• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

生物材料为癌症研究提供了第三个维度。

Biomaterials offer cancer research the third dimension.

机构信息

Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove Queensland 4059, Australia.

出版信息

Nat Mater. 2010 Feb;9(2):90-3. doi: 10.1038/nmat2619.

DOI:10.1038/nmat2619
PMID:20094076
Abstract

To deepen understanding and hasten the development of treatments, cancer needs to be modelled more accurately in vitro; applying tissue-engineering concepts and approaches in this field could bridge the gap between two-dimensional studies and in vivo animal models.

摘要

为了加深理解并加速治疗的发展,癌症需要在体外更精确地建模;在该领域应用组织工程学的概念和方法可以弥合二维研究与体内动物模型之间的差距。

相似文献

1
Biomaterials offer cancer research the third dimension.生物材料为癌症研究提供了第三个维度。
Nat Mater. 2010 Feb;9(2):90-3. doi: 10.1038/nmat2619.
2
Cell culture in autologous fibrin scaffolds for applications in tissue engineering.在自体纤维蛋白支架中进行细胞培养,应用于组织工程。
Exp Cell Res. 2014 Mar 10;322(1):1-11. doi: 10.1016/j.yexcr.2013.12.017. Epub 2013 Dec 28.
3
Novel synthesis strategies for natural polymer and composite biomaterials as potential scaffolds for tissue engineering.新型天然聚合物和复合生物材料的合成策略作为组织工程的潜在支架。
Philos Trans A Math Phys Eng Sci. 2010 Apr 28;368(1917):1981-97. doi: 10.1098/rsta.2010.0009.
4
[Recent progress on silk fibroin as tissue engineering biomaterials].[丝素蛋白作为组织工程生物材料的研究进展]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 Feb;22(2):192-5.
5
Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research.生物材料在 3D 细胞培养中的应用以及 3D 细胞培养对药物开发和基础生物医学研究的贡献。
Int J Mol Sci. 2021 Mar 2;22(5):2491. doi: 10.3390/ijms22052491.
6
[The biologic functional surfaces and their applications in tissue engineering].[生物功能表面及其在组织工程中的应用]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Oct;24(5):1177-9, 1199.
7
[Application of silk fibroin scaffold in bone tissue engineering].丝素蛋白支架在骨组织工程中的应用
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2014 Oct;28(10):1307-10.
8
Designing porous scaffolds for tissue engineering.设计用于组织工程的多孔支架。
Philos Trans A Math Phys Eng Sci. 2006 Jan 15;364(1838):227-32. doi: 10.1098/rsta.2005.1692.
9
A novel layer-structured scaffold with large pore sizes suitable for 3D cell culture prepared by near-field electrospinning.一种新型的层状结构支架,具有适合 3D 细胞培养的大孔径,通过近场静电纺丝制备。
Mater Sci Eng C Mater Biol Appl. 2018 May 1;86:18-27. doi: 10.1016/j.msec.2017.12.016. Epub 2017 Dec 15.
10
Engineered Paper-Based Cell Culture Platforms.工程化纸质细胞培养平台。
Adv Healthc Mater. 2017 Nov;6(22). doi: 10.1002/adhm.201700619. Epub 2017 Oct 27.

引用本文的文献

1
Matrix Stiffness and Biochemistry Govern Colorectal Cancer Cell Growth and Signaling in User-Programmable Synthetic Hydrogels.基质刚度和生物化学特性调控用户可编程合成水凝胶中结肠癌细胞的生长和信号传导。
ACS Biomater Sci Eng. 2025 May 12;11(5):2810-2823. doi: 10.1021/acsbiomaterials.4c01632. Epub 2025 Apr 30.
2
Decellularized extracellular matrix-based disease models for drug screening.用于药物筛选的基于脱细胞细胞外基质的疾病模型。
Mater Today Bio. 2024 Sep 27;29:101280. doi: 10.1016/j.mtbio.2024.101280. eCollection 2024 Dec.
3
Three-dimensional breast cancer tumor models based on natural hydrogels: a review.

本文引用的文献

1
Translating tissue engineering technology platforms into cancer research.将组织工程技术平台转化为癌症研究。
J Cell Mol Med. 2009 Aug;13(8A):1417-27. doi: 10.1111/j.1582-4934.2009.00853.x. Epub 2009 Jul 20.
2
Biomaterials: Spotlight on hydrogels.生物材料:聚焦水凝胶。
Nat Mater. 2009 Jun;8(6):451-3. doi: 10.1038/nmat2458.
3
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited.蛋白酶依赖性与非依赖性癌细胞侵袭程序:重新审视三维阿米巴样运动
基于天然水凝胶的三维乳腺癌肿瘤模型:综述。
J Zhejiang Univ Sci B. 2024 Sep 15;25(9):736-755. doi: 10.1631/jzus.B2300840.
4
Design approaches for 3D cell culture and 3D bioprinting platforms.3D细胞培养和3D生物打印平台的设计方法。
Biophys Rev (Melville). 2024 May 16;5(2):021304. doi: 10.1063/5.0188268. eCollection 2024 Jun.
5
Applied models and molecular characteristics of small cell lung cancer.小细胞肺癌的应用模型和分子特征。
Pathol Oncol Res. 2024 Apr 22;30:1611743. doi: 10.3389/pore.2024.1611743. eCollection 2024.
6
Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model.多组学分析确定了3D HeLa癌细胞模型中的5-氟尿嘧啶耐药性。
Bioresour Bioprocess. 2021 Dec 23;8(1):135. doi: 10.1186/s40643-021-00486-z.
7
The progressive trend of modeling and drug screening systems of breast cancer bone metastasis.乳腺癌骨转移建模及药物筛选系统的发展趋势
J Biol Eng. 2024 Feb 5;18(1):14. doi: 10.1186/s13036-024-00408-5.
8
Cassia Angustifolia Primed ASCs Accelerate Burn Wound Healing by Modulation of Inflammatory Response.窄叶土荆芥预处理脂肪间充质干细胞通过调节炎症反应加速烧伤创面愈合。
Tissue Eng Regen Med. 2024 Jan;21(1):137-157. doi: 10.1007/s13770-023-00594-1. Epub 2023 Oct 17.
9
Organ Chips and Visualization of Biological Systems.器官芯片与生物系统可视化。
Adv Exp Med Biol. 2023;1199:155-183. doi: 10.1007/978-981-32-9902-3_8.
10
Application of three-dimensional cell culture technology in screening anticancer drugs.三维细胞培养技术在抗癌药物筛选中的应用。
Biotechnol Lett. 2023 Sep;45(9):1073-1092. doi: 10.1007/s10529-023-03410-x. Epub 2023 Jul 8.
J Cell Biol. 2009 Apr 6;185(1):11-9. doi: 10.1083/jcb.200807195. Epub 2009 Mar 30.
4
New dimensions in tumor immunology: what does 3D culture reveal?肿瘤免疫学的新维度:3D 培养揭示了什么?
Trends Mol Med. 2008 Aug;14(8):333-40. doi: 10.1016/j.molmed.2008.06.001. Epub 2008 Jul 7.
5
Can cancer be reversed by engineering the tumor microenvironment?通过改造肿瘤微环境能使癌症逆转吗?
Semin Cancer Biol. 2008 Oct;18(5):356-64. doi: 10.1016/j.semcancer.2008.03.016. Epub 2008 Apr 1.
6
Peptide amphiphile nanostructure-heparin interactions and their relationship to bioactivity.肽两亲性纳米结构与肝素的相互作用及其与生物活性的关系。
Biomaterials. 2008 Aug;29(23):3298-305. doi: 10.1016/j.biomaterials.2008.04.008. Epub 2008 May 12.
7
Designer self-assembling Peptide nanofiber scaffolds for study of 3-d cell biology and beyond.用于3D细胞生物学及其他研究的定制自组装肽纳米纤维支架
Adv Cancer Res. 2008;99:335-62. doi: 10.1016/S0065-230X(07)99005-3.
8
Tissue-engineered bone serves as a target for metastasis of human breast cancer in a mouse model.在小鼠模型中,组织工程骨成为人类乳腺癌转移的靶标。
Cancer Res. 2007 Nov 1;67(21):10304-8. doi: 10.1158/0008-5472.CAN-07-2483.
9
Engineering tumors with 3D scaffolds.使用3D支架构建肿瘤模型
Nat Methods. 2007 Oct;4(10):855-60. doi: 10.1038/nmeth1085. Epub 2007 Sep 2.
10
Modeling tissue morphogenesis and cancer in 3D.三维组织形态发生与癌症建模
Cell. 2007 Aug 24;130(4):601-10. doi: 10.1016/j.cell.2007.08.006.