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糖尿病患者的血压控制:时间上的进步仍存在持续的种族差异:REasons for Geographic And Racial Differences in Stroke(REGARDS)研究的全国结果。

Blood pressure control in diabetes: temporal progress yet persistent racial disparities: national results from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.

机构信息

Department of Family Medicine, Pediatrics, and Public Health, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.

出版信息

Diabetes Care. 2010 Apr;33(4):798-803. doi: 10.2337/dc09-1824. Epub 2010 Jan 22.

Abstract

OBJECTIVE

Despite widespread dissemination of target values, achieving a blood pressure of <130/80 mmHg is challenging for many individuals with diabetes. The purpose of the present study was to examine temporal trends in blood pressure control in hypertensive individuals with diabetes as well as the potential for race, sex, and geographic disparities.

RESEARCH DESIGN AND METHODS

We analyzed baseline data from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, a national, population-based, longitudinal cohort study of 30,228 adults (58% European American and 42% African American), examining the causes of excess stroke mortality in the southeastern U.S. We calculated mean blood pressure and blood pressure control rates (proportion with blood pressure <130/80 mmHg) for 5,217 hypertensive diabetic participants by year of enrollment (2003-2007) using multivariable logistic regression models.

RESULTS

Only 43 and 30% of European American and African American diabetic hypertensive participants, respectively, demonstrated a target blood pressure of <130/80 mmHg (P < 0.001). However, a temporal trend of improved control was evident; the odds of having a blood pressure <130/80 mmHg among diabetic hypertensive participants of both races enrolled in 2007 (as compared with those enrolled in 2003) were approximately 50% greater (P < 0.001) in multivariate models.

CONCLUSIONS

These data suggest temporal improvements in blood pressure control in diabetes that may reflect broad dissemination of tighter blood pressure control targets and improving medication access. However, control rates remain low, and significant racial disparities persist among African Americans that may contribute to an increased risk for premature cardiovascular disease.

摘要

目的

尽管目标值已广泛传播,但许多患有糖尿病的个体仍难以将血压控制在<130/80mmHg 以下。本研究旨在探讨高血压合并糖尿病患者血压控制的时间趋势,以及可能存在的种族、性别和地域差异。

研究设计和方法

我们分析了 REasons for Geographic And Racial Differences in Stroke(REGARDS)研究的基线数据,该研究是一项针对美国东南部地区导致中风死亡率过高的原因的全国性、基于人群的、纵向队列研究,共纳入了 30228 名成年人(58%为欧洲裔美国人,42%为非裔美国人)。我们通过多变量逻辑回归模型,按入组年份(2003-2007 年)计算了 5517 名高血压合并糖尿病患者的平均血压和血压控制率(血压<130/80mmHg 的比例)。

结果

仅有 43%和 30%的欧洲裔美国和非裔美国糖尿病高血压患者的目标血压<130/80mmHg(P<0.001)。然而,控制情况有所改善的趋势明显;与 2003 年入组的患者相比,2007 年入组的糖尿病高血压患者血压<130/80mmHg 的可能性增加了约 50%(P<0.001),这种趋势在多变量模型中仍然存在。

结论

这些数据表明,糖尿病患者的血压控制情况在时间上有所改善,这可能反映了更严格的血压控制目标的广泛传播和改善药物的可及性。然而,控制率仍然较低,非裔美国人中仍存在显著的种族差异,这可能导致心血管疾病的风险增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8142/2845030/7ddec5e57cd4/zdc0041081890001.jpg

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