Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
Retina. 2010 Apr;30(4):596-606. doi: 10.1097/IAE.0b013e3181c10711.
The purpose of this study was to compare retinal measurements obtained using spectral domain-optical coherence tomography with measurements obtained using time domain-optical coherence tomography.
Three hundred and seventy subjects were recruited at three university-based and one community-based retina practice for a cross-sectional observational study. For each subject, one eye was enrolled as the study eye. A Stratus Fast Macular scan was performed, and a Cirrus 200 x 200 Macular Cube scan was performed. Both instruments segment the acquired images to generate retinal thickness values and report averages measured in nine subfields defined by the Early Treatment Diabetic Retinopathy Study. These average values were compared with each other quantitatively using linear regression and Bland-Altman plots.
Of the recruited subjects, 283 had acceptable images taken on the same day with both the Cirrus and Stratus devices. Mean differences between the instruments were noted in all subfields for all disease categories and ranged from 29 microm (outer superior subfield) to 54 microm (central subfield).
Differences between time domain and spectral domain measurements of retinal thickness depend on pathology and location. Comparisons across instruments should be made with caution.
本研究旨在比较使用频域光相干断层扫描（OCT）和时域光相干断层扫描（OCT）获得的视网膜测量值。
本横断面观察性研究共招募了 370 名受试者，分别来自 3 所大学附属医院和 1 所社区眼科诊所。每只眼作为研究眼纳入 1 名受试者。对所有受试者均行 Stratus 快速黄斑扫描和 Cirrus 200x200 黄斑立方扫描。这两种仪器均可对获取的图像进行分割，以生成视网膜厚度值，并通过早期糖尿病视网膜病变研究（ETDRS）定义的 9 个亚区报告平均测量值。采用线性回归和 Bland-Altman 图对这些平均值进行定量比较。
在招募的受试者中，283 名受试者在同一天使用 Cirrus 和 Stratus 设备获得了可接受的图像。在所有疾病类别和所有亚区中，两种仪器的平均差异均有记录，范围从 29 微米（外上方亚区）到 54 微米（中央亚区）。
视网膜厚度的时域和频域测量值之间的差异取决于病变和位置。在跨仪器比较时应谨慎。
