Ligtenberg P C, Hoepelman I M, Oude Sogtoen G A, Dekker A W, van der Tweel I, Rozenberg-Arska M, Verhoef J
Department of Internal Medicine, University Hospital, Utrecht, The Netherlands.
Eur J Clin Microbiol Infect Dis. 1991 Jan;10(1):25-31. doi: 10.1007/BF01967093.
The serum levels of C-reactive protein (CRP) were assayed in 64 non-granulocytopenic and 35 granulocytopenic patients with or without fever and infection. Most patients showed a direct CRP response within 24 hours after onset of fever (95% of non-granulocytopenic patients, 100% of granulocytopenic patients). The mean peak level of CRP in febrile patients with septicemia was 207 mg/l (median 214 mg/l) in non-granulocytopenic patients and 173 mg/l (median 168 mg/l) in granulocytopenic patients, and differed significantly (p less than 0.001) from that in febrile patients without positive blood cultures. A significant difference between patients with major and minor infections was also found (p less than 0.01). No significant difference in the CRP level was found between patients with microbiologically and clinically documented infections (p greater than 0.05), nor did the serum CRP levels differ between patients with infections due to gram-positive and gram-negative organisms. The most favorable cut-off limit for detection of an inflammatory process in this study was 25 mg/l. There was no quantitative difference between CRP levels measured by a latex-agglutination method and the nephelometry assay.
对64例非粒细胞减少和35例粒细胞减少的患者（无论有无发热和感染）测定了血清C反应蛋白（CRP）水平。大多数患者在发热开始后24小时内出现CRP直接反应（95%的非粒细胞减少患者，100%的粒细胞减少患者）。败血症发热患者中，非粒细胞减少患者CRP的平均峰值水平为207mg/L（中位数214mg/L），粒细胞减少患者为173mg/L（中位数168mg/L），与血培养阴性的发热患者相比有显著差异（p<0.001）。在主要感染和轻微感染患者之间也发现了显著差异（p<0.01）。微生物学和临床记录感染的患者之间CRP水平无显著差异（p>0.05），革兰氏阳性菌和革兰氏阴性菌感染的患者血清CRP水平也无差异。本研究中检测炎症过程的最适临界值为25mg/L。乳胶凝集法和散射比浊法测定的CRP水平无定量差异。
