Dinc Umut A, Kulacoglu Destan N, Oncei Banu, Yalvac Ilgaz Sagdic
Ophthalmology Department, Yeditepe University Eye Hospital, Istanbul, Turkey.
Eur J Ophthalmol. 2010 Jul-Aug;20(4):702-7. doi: 10.1177/112067211002000410.
To quantitatively assess the parameters of anterior chamber and angle dimensions by slit-lamp optical coherence tomography (SL-OCT) in eyes with pigmentary glaucoma (PG).
A total of 18 eyes of 11 patients with PG and 18 eyes of 11 healthy volunteers were included in the study. Anterior chamber depth (ACD), anterior chamber volume (ACV), spur distance (internal horizontal anterior chamber diameter), central corneal thickness (CCT), angle opening distance at 500 microm from the scleral spur (AOD 500), and trabecular iris space area at 500 microm from the scleral spur (TISA 500) parameters were detected by SL-OCT. The differences of anterior chamber parameters between patients with PG and the control group were analyzed by Mann-Whitney U test.
Mean ACD and ACV were measured as 3.28 +/- 0.38 mm and 191.6 +/- 39.7 mm3 respectively in the PG group. Mean AOD 500 and TISA 500 were 0.88 +/- 0.47 mm and 0.29 +/- 0.15 mm2 at the nasal angle and 1.14 +/- 0.67 mm and 0.41 +/- 0.23 mm2 at the temporal angle, respectively. Nasal and temporal angles were 49.83 +/- 11.1 degrees and 53.83 +/- 10.46 degrees. In eyes with PG, the midperipheral iris configuration was found to be considerably concave in 15 eyes (83.3%). Except CCT and spur distance, all anterior chamber dimension and angle parameters detected by SL-OCT were found to be significantly higher in the eyes with PG (Mann-Whitney U test, p < 0.05). CONCLUSIONS. SL-OCT provided highly quantitative data on the parameters of anterior chamber and angle dimensions in PG. The evaluation of the anterior segment anatomy using SL-OCT revealed increased anterior chamber dimensions and posterior bowing of the iris consistent with the increase in angle parameters in patients with PG.
通过裂隙灯光学相干断层扫描（SL-OCT）定量评估色素性青光眼（PG）患者前房和房角参数。
本研究纳入11例PG患者的18只眼和11名健康志愿者的18只眼。通过SL-OCT检测前房深度（ACD）、前房容积（ACV）、嵴距（前房内水平直径）、中央角膜厚度（CCT）、距巩膜嵴500微米处的房角开放距离（AOD 500）以及距巩膜嵴500微米处的小梁虹膜间隙面积（TISA 500）参数。采用Mann-Whitney U检验分析PG患者与对照组前房参数的差异。
PG组平均ACD和ACV分别为3.28±0.38毫米和191.6±39.7立方毫米。鼻侧房角平均AOD 500和TISA 500分别为0.88±0.47毫米和0.29±0.15平方毫米，颞侧房角分别为1.14±0.67毫米和0.41±0.23平方毫米。鼻侧和颞侧房角分别为49.83±11.1度和53.83±10.46度。在PG患者眼中，15只眼（83.3%）的周边虹膜形态明显凹陷。除CCT和嵴距外，SL-OCT检测的所有前房尺寸和房角参数在PG患者眼中均显著更高（Mann-Whitney U检验，p<0.05）。结论：SL-OCT为PG患者的前房和房角参数提供了高度定量的数据。使用SL-OCT对眼前节解剖结构的评估显示，PG患者前房尺寸增加，虹膜后凸，与房角参数增加一致。
