de Ziegler D, Bessis R, Frydman R
University of Paris, Hôpital A. Béclère, Clamart, France.
Fertil Steril. 1991 Apr;55(4):775-9.
To determine if reproductive hormones played a role at physiological levels on vascular resistance of uterine arteries, we studied young women having inactive ovaries who received exogenous estradiol (E2) and progesterone (P). Six women, ages 27 to 36 with absent or nonfunctioning ovaries, received transdermal E2 and vaginal P after a 28-day replacement regimen duplicating E2 and P levels seen in the menstrual cycle. Vascular resistance of uterine arteries was evaluated before treatment (baseline), on days 13 to 14 and on days 26 to 27, using transvaginal pulsed Doppler combined with real-time imaging. Doppler waveforms were analyzed by the pulsatility index (PI). Baseline evaluation showed narrow systolic Doppler flow waves with a PI of 5.2 +/- 0.4, mean +/- SEM. On cycle day 13, Doppler waveforms showed a marked broadening with uninterrupted diastolic flow indicative of a profound decrease in vascular resistance. This was reflected by a significant decrease in PI to 1.3 +/- 0.3, mean +/- SEM. Doppler measurements made on days 26 to 27 showed no significant change. Our results indicate that at physiological levels, E2 affects vascular resistance of uterine arteries. This represents a new parameter of estrogen action, readily measurable by a noninvasive technique that, in the future, may help for assessing the efficacy of various estrogenic treatments.
为了确定生殖激素在生理水平上是否对子宫动脉血管阻力有影响，我们研究了卵巢功能不活跃的年轻女性，她们接受了外源性雌二醇（E2）和孕酮（P）。6名年龄在27至36岁、卵巢缺失或功能丧失的女性，在经过28天的替代方案，使E2和P水平达到月经周期所见水平后，接受经皮E2和阴道P治疗。在治疗前（基线）、第13至14天以及第26至27天，使用经阴道脉冲多普勒结合实时成像评估子宫动脉的血管阻力。通过搏动指数（PI）分析多普勒波形。基线评估显示收缩期多普勒血流波狭窄，PI为5.2 +/- 0.4，均值 +/- 标准误。在周期第13天，多普勒波形显示明显增宽，舒张期血流不间断，表明血管阻力显著降低。这表现为PI显著降至1.3 +/- 0.3，均值 +/- 标准误。在第26至27天进行的多普勒测量显示无显著变化。我们的结果表明，在生理水平上，E2会影响子宫动脉的血管阻力。这代表了雌激素作用的一个新参数，可通过一种非侵入性技术轻松测量，未来可能有助于评估各种雌激素治疗的疗效。
