Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
Diabetes. 2010 Apr;59(4):1026-9. doi: 10.2337/db09-1316. Epub 2010 Jan 26.
Insulin resistance might play a role in the pathogenesis of polycystic ovarian syndrome (PCOS). The family of glycoprotein 130 (gp130) cytokines could influence insulin action. One of these cytokines is interleukin (IL)-6, which exerts a short-term insulin-sensitizing effect, whereas in a long-term period, it might induce insulin resistance. Some other gp130 activators are supposed to have beneficial metabolic effects. Gp130 is present in the circulation in the soluble form (sgp130), which inhibits intracellular gp130 signaling. The aim of the present study was to estimate the relation between sgp130 and insulin sensitivity in women with PCOS.
We studied 78 women with PCOS (35 lean and 43 obese) and 34 healthy women (18 lean and 16 obese). The euglycemic-hyperinsulinemic clamp and the measurements of serum sgp130, IL-6, soluble IL-6 receptor (sIL-6R), and sex hormones were performed.
Both obesity and PCOS were characterized by an increased sgp130 (P < 0.0001 and P = 0.0002, respectively). sIL-6R concentration was lower (P = 0.0036) in women with PCOS independently of obesity. Serum sgp130 was negatively correlated with insulin sensitivity when control and PCOS women were analyzed together (r = -0.36, P < 0.0001) and in the PCOS subjects separately (r = -0.34, P = 0.002). In multiple regression analysis, this correlation was significant after adjustment for BMI, waist, percent of body fat, postload glucose and insulin, triglycerides, and high-sensitive C-reactive protein.
Serum sgp130 is inversely and independently associated with insulin sensitivity in women with PCOS. An increased serum sgp130 in obesity and PCOS suggests an inhibition of intracellular gp130 signaling in insulin-resistant conditions.
胰岛素抵抗可能在多囊卵巢综合征（PCOS）的发病机制中起作用。糖蛋白 130（gp130）细胞因子家族可以影响胰岛素作用。其中一种细胞因子是白细胞介素（IL）-6，它发挥短期胰岛素增敏作用，而在长期内，它可能导致胰岛素抵抗。其他一些 gp130 激活剂具有有益的代谢作用。gp130 以可溶形式（sgp130）存在于循环中，可抑制细胞内 gp130 信号传导。本研究旨在评估 PCOS 妇女血清 sgp130 与胰岛素敏感性之间的关系。
我们研究了 78 名 PCOS 妇女（35 名瘦人和 43 名肥胖者）和 34 名健康妇女（18 名瘦人和 16 名肥胖者）。进行了正常血糖高胰岛素钳夹试验和血清 sgp130、IL-6、可溶性 IL-6 受体（sIL-6R）和性激素的测量。
肥胖和 PCOS 均表现出 sgp130 增加（P<0.0001 和 P=0.0002）。PCOS 妇女的 sIL-6R 浓度较低（P=0.0036），无论肥胖与否。当一起分析对照组和 PCOS 妇女时，血清 sgp130 与胰岛素敏感性呈负相关（r=-0.36，P<0.0001），并且在 PCOS 患者中分别为（r=-0.34，P=0.002）。在多元回归分析中，在调整 BMI、腰围、体脂肪百分比、负荷后血糖和胰岛素、甘油三酯和高敏 C 反应蛋白后，这种相关性仍然显著。
血清 sgp130 与 PCOS 妇女的胰岛素敏感性呈负相关且独立相关。肥胖和 PCOS 中血清 sgp130 的增加表明在胰岛素抵抗条件下细胞内 gp130 信号的抑制。
