FRAME, animal experimentation and the Three Rs: past, present and future.

At the opening of a meeting to celebrate the 50th anniversary of the publication of The Principles of Humane Experimental Technique, by W.M.S. Russell and R.L. Burch, and the 40th anniversary of the establishment of FRAME, some comments on the early days of the Charity are made, with particular reference to the special contributions made by its founder-Chairman, Dorothy Hegarty, and the author's own appointment as a Trustee, and later as Chairman. Reference is made to some key events and successes, and especially to the importance of FRAME's move from London to Nottingham, and the establishment of an ongoing collaboration with the University of Nottingham, including the setting-up of the FRAME Alternatives Laboratory.