School of Health and Population Sciences, University of Birmingham, Birmingham, UK.
Exp Brain Res. 2010 May;202(3):591-604. doi: 10.1007/s00221-010-2162-1. Epub 2010 Jan 28.
This study quantitatively describes differences between participants with hemiparetic stroke and age-matched healthy participants in axial body segment and gait kinematics during a direction change task. Participants were required to change walking direction by 45 degrees, either to their left or right, at the midpoint of a 6-m path. Participants were visually cued either at the start of the walk (pre-planned) or one stride before they reached the turn point (reactive). The sequence and inter-segmental timing of axial orientation onset was preserved in participants with stroke. Analysis of a subgroup of stroke survivors indicated that participants with lesions affecting the basal ganglia (BG) took significantly longer time than control participants to initiate the reorientation synergy when making turns to their non-paretic side. We hypothesize that these differences are a product of asymmetrical activity of dopaminergic pathways in the brain resulting from compromised BG function.
本研究定量描述了偏瘫中风患者与年龄匹配的健康参与者在 6 米路径中点进行方向改变任务时轴向身体节段和步态运动学的差异。参与者被要求向左或向右改变行走方向 45 度。参与者在行走开始时（预先计划）或到达转弯点前一步（反应性）接受视觉提示。中风患者的轴向定向起始的序列和节段间定时得以保留。对中风幸存者亚组的分析表明，与对照组相比，病变影响基底节（BG）的参与者在向非瘫痪侧转弯时，启动重新定向协同作用的时间明显更长。我们假设这些差异是大脑中多巴胺能通路的不对称活动的产物，这是由于 BG 功能受损所致。
