Dept of Cell Biology and Physiology, Washington University, St Louis, MO 63110, United States.
Semin Cell Dev Biol. 2010 May;21(3):283-9. doi: 10.1016/j.semcdb.2010.01.020. Epub 2010 Jan 28.
In many cell divisions, the position of the spindle apparatus is coordinated with polarity signals at the cell cortex so that copies of the genome are delivered to regions of the cell that are designated for differential inheritance by the two progeny. To coordinate spindle position with cell polarity, the spindle interfaces with elements on the cortex, where molecular motors often produce the forces that power displacement. Here we describe the molecular pathways by which cortical motors translocate the spindle in budding yeast, where the mechanisms are understood relatively well, and we compare these pathways to spindle positioning processes in metazoan systems, where the molecular details are less well understood.
在许多细胞分裂中，纺锤体装置的位置与细胞皮层的极性信号相协调，以便基因组的副本被传递到细胞的特定区域，这些区域被两个后代指定用于不同的遗传。为了协调纺锤体的位置和细胞极性，纺锤体与皮层上的元件相互作用，分子马达通常产生使位移发生的力。在这里，我们描述了芽殖酵母中皮质马达使纺锤体移位的分子途径，在这些途径中，机制相对较好理解，我们将这些途径与后生动物系统中的纺锤体定位过程进行比较，在这些系统中，分子细节不太清楚。
