Microbial Genomics Group, Center for Biological Sequence Analysis, TechnicalUniversity of Denmark, Lyngby, Denmark.
J Med Microbiol. 2010 Apr;59(Pt 4):392-399. doi: 10.1099/jmm.0.008672-0. Epub 2010 Jan 28.
Many bacterial infections are associated with biofilm formation. Bacterial biofilms can develop on essentially all kinds of surfaces, producing chronic and often intractable infections. Escherichia coli is an important pathogen causing a wide range of gastrointestinal infections. E. coli strain Nissle 1917 has been used for many decades as a probiotic against a variety of intestinal disorders and is probably the best field-tested E. coli strain in the world. Here we have investigated the biofilm-forming capacity of Nissle 1917. We found that the strain was a good biofilm former. Not only was it significantly better at biofilm formation than enteropathogenic, enterotoxigenic and enterohaemorrhagic E. coli strains, it was also able to outcompete such strains during biofilm formation. The results support the notion of bacterial prophylaxis employing Nissle 1917 and may partially explain why the strain has a beneficial effect on many intestinal disorders.
许多细菌感染都与生物膜形成有关。细菌生物膜可以在基本上所有类型的表面上形成，导致慢性且常常难以治疗的感染。大肠杆菌是一种重要的病原体，可引起多种胃肠道感染。Nissle 1917 大肠杆菌菌株已被使用了几十年，作为一种益生菌，用于治疗各种肠道疾病，并且可能是世界上经过最充分测试的大肠杆菌菌株。在这里，我们研究了 Nissle 1917 的生物膜形成能力。我们发现该菌株是一种良好的生物膜形成者。它不仅比肠致病性、肠毒性和肠出血性大肠杆菌菌株更擅长生物膜形成，而且在生物膜形成过程中也能够与这些菌株竞争。这些结果支持使用 Nissle 1917 进行细菌预防的观点，并可能部分解释为什么该菌株对许多肠道疾病具有有益的影响。
