Puthran Shilpa S, Sudha K, Rao Gayathri M, Shetty Beena V
Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Bejai, Mangalore - 575 004.
Indian J Physiol Pharmacol. 2009 Apr-Jun;53(2):181-4.
The field of radiation biochemistry has provided tremendous impact in recent years as extensive research on free radicals has implicated them in radiation damage. An important offshoot of this field is the branch dealing with radiological protection in medical applications like diagnostic radiology. Hence, we decided to investigate the relationship between oxidative stress and low dose ionizing radiation (x-rays) in the work environment of x-ray technicians (radiographers), by comparing their RBC malondialdehyde, % hemolysis, catalase and plasma vitamin E levels with those of controls. There was a significant increase in the susceptibility of RBCs to hemolysis in radiographers compared to controls. Malondialdehyde and catalase levels were slightly increased in the radiographers, but this did not disturb the steady state concentration of their plasma vitamin E. These findings go in favour of theories stating that exposure to low dose ionizing radiation does cause a greater amount of oxidative stress, than that caused during normal routine metabolic processes.
近年来，辐射生物化学领域产生了巨大影响，因为对自由基的广泛研究表明它们与辐射损伤有关。该领域的一个重要分支是处理医学应用（如诊断放射学）中的放射防护问题。因此，我们决定通过比较X射线技术人员（放射技师）工作环境中红细胞丙二醛、溶血百分比、过氧化氢酶和血浆维生素E水平与对照组的水平，来研究氧化应激与低剂量电离辐射（X射线）之间的关系。与对照组相比，放射技师红细胞对溶血的敏感性显著增加。放射技师的丙二醛和过氧化氢酶水平略有升高，但这并未干扰其血浆维生素E的稳态浓度。这些发现支持了这样的理论，即暴露于低剂量电离辐射确实会比正常日常代谢过程中产生更多的氧化应激。
