Kao K R, Hopwood N D
Cancer Research Campaign, Wellcome/CRC Institute, Cambridge, England.
Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2697-701. doi: 10.1073/pnas.88.7.2697.
We describe a Xenopus mRNA, Xrel1, that is related to the avian protooncogene c-rel, the embryonic pattern gene dorsal of Drosophila, and the mammalian transcription factor NK-kappa B/KBF1. The sequence of Xrel1 is homologous to the other rel-related proteins in the large amino-terminal region that defines this class of transcriptional regulators, but the carboxyl-terminal part of the protein is quite different. Xrel1 mRNA is present throughout oogenesis and during early embryogenesis at 4 x 10(5) transcripts per oocyte or embryo. Xrel1 transcripts are present in all of the dissected parts of early embryos that we have examined. They are enriched in the animal hemisphere compared to the vegetal hemisphere of oocytes and blastulae.
我们描述了一种非洲爪蟾mRNA，即Xrel1，它与禽原癌基因c-rel、果蝇的胚胎模式基因背腹基因以及哺乳动物转录因子NK-κB/KBF1相关。Xrel1的序列在定义这类转录调节因子的大的氨基末端区域与其他rel相关蛋白同源，但该蛋白的羧基末端部分则有很大不同。Xrel1 mRNA在整个卵子发生过程以及早期胚胎发生期间均有存在，每个卵母细胞或胚胎中有4×10⁵个转录本。我们检查过的早期胚胎的所有解剖部分中都有Xrel1转录本。与卵母细胞和囊胚的植物半球相比，它们在动物半球中更为富集。
