Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, 0316 Oslo, Norway.
Eur J Nutr. 2010 Sep;49(6):345-55. doi: 10.1007/s00394-010-0092-0. Epub 2010 Feb 2.
Bilberries are abundant in polyphenols. Dietary polyphenols have been associated with strategies for prevention and treatment of chronic inflammatory diseases. We investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD).
In a randomized controlled trial, participants consumed either bilberry juice (n = 31) or water (n = 31) for 4 weeks.
Supplementation with bilberry juice resulted in significant decreases in plasma concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-15, and monokine induced by INF-gamma (MIG). Unexpectedly, an increase in the plasma concentration of tumor nuclear factor-alpha (TNF-alpha) was observed in the bilberry group. CRP, IL-6, IL15, MIG, and TNF-alpha are all target genes of nuclear factor- kappa B (NF-kappaB), -a transcription factor that is crucial in orchestrating inflammatory responses. Plasma quercetin and p-coumaric acid increased in the bilberry group, otherwise no differences were observed for clinical parameters, oxidative stress or antioxidant status. Furthermore, we studied the effect of polyphenols from bilberries on lipopolysaccharide (LPS)-induced NF-kappaB activation in a monocytic cell line. We observed that quercetin, epicatechin, and resveratrol inhibited NF-kappaB activation.
These findings suggest that supplementation with bilberry polyphenols may modulate the inflammation processes. Further testing of bilberry supplementation as a potential strategy in prevention and treatment of chronic inflammatory diseases is warranted.
越橘富含多酚。饮食多酚与预防和治疗慢性炎症性疾病的策略有关。我们研究了越橘汁对至少有一种心血管疾病（CVD）风险因素升高的受试者的血清和血浆炎症及抗氧化状态生物标志物的影响。
在一项随机对照试验中，参与者连续 4 周分别饮用越橘汁（n = 31）或水（n = 31）。
补充越橘汁可显著降低血浆 C 反应蛋白（CRP）、白细胞介素（IL）-6、IL-15 和干扰素-γ诱导的单核细胞因子（MIG）浓度。出乎意料的是，在越橘组中观察到血浆肿瘤核因子-α（TNF-α）浓度增加。CRP、IL-6、IL15、MIG 和 TNF-α均为核因子-κB（NF-κB）的靶基因，NF-κB是调节炎症反应的关键转录因子。血浆槲皮素和对香豆酸在越橘组中增加，否则未观察到临床参数、氧化应激或抗氧化状态的差异。此外，我们研究了越橘多酚对单核细胞系中脂多糖（LPS）诱导的 NF-κB 激活的影响。我们观察到槲皮素、表儿茶素和白藜芦醇抑制 NF-κB 激活。
这些发现表明，补充越橘多酚可能调节炎症过程。进一步测试越橘补充剂作为预防和治疗慢性炎症性疾病的潜在策略是必要的。
