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本文引用的文献

1
Habitual intake of dietary flavonoids and risk of Parkinson disease.习惯性摄入膳食黄酮类化合物与帕金森病风险。
Neurology. 2012 Apr 10;78(15):1138-45. doi: 10.1212/WNL.0b013e31824f7fc4. Epub 2012 Apr 4.
2
Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment.不宁腿综合征：流行病学、风险因素和治疗的全面概述。
Sleep Breath. 2012 Dec;16(4):987-1007. doi: 10.1007/s11325-011-0606-x. Epub 2011 Oct 26.
3
Use of ibuprofen and risk of Parkinson disease.布洛芬的使用与帕金森病风险。
Neurology. 2011 Mar 8;76(10):863-9. doi: 10.1212/WNL.0b013e31820f2d79. Epub 2011 Mar 2.
4
Prevalence and clinical profile of restless legs syndrome in Parkinson's disease.帕金森病患者不安腿综合征的患病率和临床特征。
Mov Disord. 2010 Oct 15;25(13):2142-7. doi: 10.1002/mds.23241.
5
Restless legs syndrome and Parkinson's disease in men.男性不宁腿综合征与帕金森病。
Mov Disord. 2010 Nov 15;25(15):2654-7. doi: 10.1002/mds.23256.
6
Transcranial brain sonography in Parkinson's disease with restless legs syndrome.经颅脑超声在帕金森病伴不宁腿综合征中的应用。
Mov Disord. 2010 Jul 30;25(10):1373-8. doi: 10.1002/mds.23066.
7
Restless Legs Syndrome (RLS) and Parkinson's disease (PD)-related disorders or different entities?不宁腿综合征（RLS）与帕金森病（PD）相关障碍或不同实体？
J Neurol Sci. 2010 Feb 15;289(1-2):135-7. doi: 10.1016/j.jns.2009.08.035. Epub 2009 Sep 15.
8
Restless legs syndrome in Parkinson's disease.帕金森病相关的不宁腿综合征。
Mov Disord. 2009 Oct 30;24(14):2076-80. doi: 10.1002/mds.22694.
9
Factors contributing to the development of restless legs syndrome in patients with Parkinson disease.帕金森病患者出现不宁腿综合征的相关因素。
Mov Disord. 2009 Mar 15;24(4):579-82. doi: 10.1002/mds.22410.
10
A critical evaluation of the Braak staging scheme for Parkinson's disease.对帕金森病Braak分期方案的批判性评估。
Ann Neurol. 2008 Nov;64(5):485-91. doi: 10.1002/ana.21541.

不宁腿综合征：男性帕金森病的早期临床特征。

Restless legs syndrome: an early clinical feature of Parkinson disease in men.

作者信息

Wong Janice C, Li Yanping, Schwarzschild Michael A, Ascherio Alberto, Gao Xiang

机构信息

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Department of Nutrition, Harvard School of Public Health, Boston, MA.

出版信息

Sleep. 2014 Feb 1;37(2):369-72. doi: 10.5665/sleep.3416.

DOI:10.5665/sleep.3416
PMID:24497665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3900617/
Abstract

STUDY OBJECTIVE

The association between restless legs syndrome (RLS) and Parkinson disease has been extensively studied, but the temporal relationship between the two remains unclear. We thus conduct the first prospective study to examine the risk of developing Parkinson disease in RLS.

DESIGN

Prospective study from 2002-2010.

SETTING

United States.

PARTICIPANTS

There were 22,999 US male health professionals age 40-75 y enrolled in the Health Professionals Follow-up Study without Parkinson disease, arthritis, or diabetes mellitus at baseline.

MEASUREMENT AND RESULTS

RLS was assessed in 2002 using a set of standardized questions recommended by the International RLS Study Group. Incident Parkinson disease was identified by biennial questionnaires and then confirmed by review of participants' medical records by a movement disorder specialist. We documented 200 incident Parkinson disease cases during 8 y of follow-up. Compared to men without RLS, men with RLS symptoms who had symptoms greater than 15 times/mo had higher risk of Parkinson disease development (adjusted relative risk = 1.47; 95% confidence interval: 0.59, 3.65; P = 0.41). This was statistically significant only for cases diagnosed within 4 y of follow-up (adjusted relative risk = 2.77; 95% confidence interval: 1.08, 7.11; P = 0.03).

CONCLUSION

Severe restless legs syndrome may be an early feature of Parkinson disease.

摘要

研究目的

不安腿综合征（RLS）与帕金森病之间的关联已得到广泛研究，但两者之间的时间关系仍不明确。因此，我们开展了第一项前瞻性研究，以检验不安腿综合征患者患帕金森病的风险。

设计

2002年至2010年的前瞻性研究。

地点

美国。

参与者

22999名年龄在40 - 75岁的美国男性健康专业人员参与了健康专业人员随访研究，基线时无帕金森病、关节炎或糖尿病。

测量与结果

2002年使用国际不安腿综合征研究组推荐的一组标准化问题对不安腿综合征进行评估。通过每两年一次的问卷调查确定帕金森病发病情况，然后由运动障碍专家查阅参与者的病历进行确认。在8年的随访期间，我们记录了200例帕金森病发病病例。与无不安腿综合征的男性相比，每月症状出现超过15次的有不安腿综合征症状的男性患帕金森病的风险更高（调整后的相对风险 = 1.47；95%置信区间：0.59，3.65；P = 0.41）。仅在随访4年内确诊的病例中，这一结果具有统计学意义（调整后的相对风险 = 2.77；95%置信区间：1.08，7.11；P = 0.03）。

结论

严重的不安腿综合征可能是帕金森病的早期特征。