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多黏菌素B和利福平：治疗多重耐药粘质沙雷菌感染的新方案。

Polymyxin B and rifampin: new regimen for multiresistant Serratia marcescens infections.

作者信息

Ostenson R C, Fields B T, Nolan C M

出版信息

Antimicrob Agents Chemother. 1977 Dec;12(6):655-9. doi: 10.1128/AAC.12.6.655.

DOI:10.1128/AAC.12.6.655
PMID:201214
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429999/
Abstract

Polymyxin B and rifampin were given to 12 patients with multi-drug-resistant nosocomial Serratia marcescens infections. Eight cures were achieved; drug hepatotoxicity occurred once; one fatal suprainfection was encountered; and two patients died during therapy of causes related to severe underlying illnesses. Polymyxin B and rifampin were uniformly synergistic in vitro against the infecting strains and against 40 additional clinical isolates of S. marcescens.

摘要

对12例耐多药的医院内粘质沙雷菌感染患者给予多粘菌素B和利福平治疗。8例治愈；发生过1次药物肝毒性；出现1例致命的二重感染；2例患者在治疗期间因严重基础疾病相关原因死亡。多粘菌素B和利福平在体外对感染菌株以及另外40株临床分离的粘质沙雷菌均具有一致的协同作用。

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Polymyxin B and rifampin: new regimen for multiresistant Serratia marcescens infections.多黏菌素B和利福平：治疗多重耐药粘质沙雷菌感染的新方案。
Antimicrob Agents Chemother. 1977 Dec;12(6):655-9. doi: 10.1128/AAC.12.6.655.
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本文引用的文献

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Bacterial colonization and clinical superinfection of the respiratory tract complicating antibiotic treatment of pneumonia.呼吸道细菌定植及临床二重感染使肺炎的抗生素治疗复杂化。
J Infect Dis. 1969 Jun;119(6):597-624. doi: 10.1093/infdis/119.6.597.
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The polymyxins.多粘菌素类
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Emergence of resistance to amikacin during treatment of burn wounds: the role of antimicrobial susceptibility testing.烧伤创面治疗期间对阿米卡星耐药性的出现：抗菌药物敏感性试验的作用
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Amikacin therapy for serious gram-negative bacillary infections.阿米卡星治疗严重革兰氏阴性杆菌感染。
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Amikacin therapy for severe gram-negative sepsis. Emphasis on infections with gentamicin-resistant organisms.阿米卡星治疗严重革兰氏阴性菌败血症。重点关注对庆大霉素耐药菌的感染。
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Comparison of methods for assessing in vitro antibiotic synergism against Pseudomonas and Serratia.评估针对假单胞菌属和沙雷氏菌属的体外抗生素协同作用方法的比较
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Amikacin therapy of patients with multiply antibiotic-resistant Serratia marcescens infections: development of increasing resistance during therapy.用阿米卡星治疗多重耐药性粘质沙雷菌感染患者：治疗期间耐药性增强的情况。
Am J Med. 1977 Jun;62(6):902-10. doi: 10.1016/0002-9343(77)90659-3.
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Sulfamethoxazole-trimethoprim-polymyxin therapy of serious multiply drug-resistant Serratia infections.复方新诺明-多粘菌素治疗严重多重耐药性沙雷菌感染
Antimicrob Agents Chemother. 1976 Feb;9(2):201-7. doi: 10.1128/AAC.9.2.201.
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In vitro additive effect of polymxin B and rifampin against Serratia marcesen.多粘菌素B和利福平对粘质沙雷氏菌的体外相加作用。
Antimicrob Agents Chemother. 1975 Jun;7(6):874-6. doi: 10.1128/AAC.7.6.874.
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Detection of Serratia outbreaks in hospital.医院中沙雷氏菌暴发的检测。
Lancet. 1976 Aug 28;2(7983):455-9. doi: 10.1016/s0140-6736(76)92539-3.