Psychology Department, Stanford University, USA.
Neuroimage. 2010 May 15;51(1):421-31. doi: 10.1016/j.neuroimage.2010.01.089. Epub 2010 Feb 1.
A network of prefrontal and parietal regions has been implicated in executive control processes. However, the extent to which individual regions within this network are engaged in component control processes, such as inhibition of task-irrelevant stimulus attributes or shifting (switching) between attentional foci, remains controversial. Participants (N=17) underwent functional magnetic resonance imaging while performing a global-local task in which the global and local levels could facilitate or interfere with one another. Stimuli were presented in blocks in which participants either constantly shifted between the global and local levels, or consistently responded to one level only. Activations related to inhibition and shifting processes were observed in a large network of bilateral prefrontal, parietal, and basal ganglia regions. Region of interest analyses were used to classify each region within this network as being common to inhibition and shifting, or preferential to one component process. Several regions were classified as being preferential to inhibition, including regions within the dorsolateral and ventrolateral prefrontal cortex, the parietal lobes, and the temporal-parietal junction. A limited set of regions in the parietal lobes and left dorsolateral prefrontal cortex were classified as preferential to shifting. There was a very large set of regions displaying activation common to both inhibition and shifting processes, including regions within the dorsolateral prefrontal cortex, anterior cingulate, and basal ganglia. Several of these common regions were also involved during facilitation, suggesting that they are responsive to the number of task-salient channels of information, rather than purely to demands on control processes.
前额叶和顶叶区域网络被牵连到执行控制过程中。然而，在这个网络中，个体区域在组件控制过程（如抑制任务不相关的刺激属性或注意力焦点的转移（切换））中被激活的程度仍然存在争议。参与者（N=17）在执行全局-局部任务时接受了功能磁共振成像，在该任务中，全局和局部水平可以相互促进或干扰。刺激以块的形式呈现，参与者要么在全局和局部水平之间不断切换，要么始终只对一个水平做出反应。在一个由双侧前额叶、顶叶和基底神经节区域组成的大型网络中观察到与抑制和转移过程相关的激活。使用感兴趣区域分析将这个网络中的每个区域分类为共同抑制和转移，或优先于一个组件过程。几个区域被归类为优先抑制，包括背外侧和腹外侧前额叶皮层、顶叶和颞顶联合区的区域。顶叶和左背外侧前额叶皮层的一组有限的区域被归类为优先转移。有一大组区域显示出与抑制和转移过程共同激活的区域，包括背外侧前额叶皮层、前扣带和基底神经节内的区域。这些共同区域中的几个也参与了促进，这表明它们对任务显著信息通道的数量有反应，而不仅仅是对控制过程的需求。
