Department of Chemistry, Drexel University, Philadelphia, Pennsylvania 19010, USA.
Anal Chem. 2010 Mar 1;82(5):1634-42. doi: 10.1021/ac901955d.
Microcantilever sensor technology has been steadily growing for the last 15 years. While we have gained a great amount of knowledge in microcantilever bending due to surface stress changes, which is a unique property of microcantilever sensors, we are still in the early stages of understanding the fundamental surface chemistries of surface-stress-based microcantilever sensors. In general, increasing surface stress, which is caused by interactions on the microcantilever surfaces, would improve the S/N ratio and subsequently the sensitivity and reliability of microcantilever sensors. In this review, we will summarize (A) the conditions under which a large surface stress can readily be attained and (B) the strategies to increase surface stress in case a large surface stress cannot readily be reached. We will also discuss our perspectives on microcantilever sensors based on surface stress changes.
微悬臂梁传感器技术在过去的 15 年中稳步发展。虽然我们已经通过表面应力变化获得了大量关于微悬臂梁弯曲的知识，这是微悬臂梁传感器的独特特性，但我们仍处于理解基于表面应力的微悬臂梁传感器的基本表面化学的早期阶段。一般来说，增加微悬臂梁表面相互作用引起的表面应力会提高信噪比，从而提高微悬臂梁传感器的灵敏度和可靠性。在本综述中，我们将总结（A）易于获得大表面应力的条件，以及（B）在不易获得大表面应力的情况下增加表面应力的策略。我们还将讨论我们对基于表面应力变化的微悬臂梁传感器的看法。
