Coronary plaque neovascularization and hemorrhage: a potential target for plaque stabilization?
作者信息
Finn Aloke V, Jain Rakesh K
出版信息
JACC Cardiovasc Imaging. 2010 Jan;3(1):41-4. doi: 10.1016/j.jcmg.2009.11.001.
Abstract
摘要
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本文引用的文献
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A new target for tumor therapy.肿瘤治疗的新靶点。
N Engl J Med. 2009 Jun 18;360(25):2669-71. doi: 10.1056/NEJMcibr0902054.
2
Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage.人类冠状动脉粥样硬化斑块中的薄壁微血管显示出不完整的内皮连接，这与斑块内微血管渗漏的结构完整性受损有关。
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A role for VEGF as a negative regulator of pericyte function and vessel maturation.血管内皮生长因子作为周细胞功能和血管成熟的负调节因子的作用。
Nature. 2008 Dec 11;456(7223):809-13. doi: 10.1038/nature07424. Epub 2008 Nov 9.
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Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.人类动脉粥样硬化斑块中的缺氧、缺氧诱导转录因子和巨噬细胞与斑块内血管生成相关。
J Am Coll Cardiol. 2008 Apr 1;51(13):1258-65. doi: 10.1016/j.jacc.2007.12.025.
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Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic plaques with high microvessel density.在微血管密度高的动脉粥样硬化斑块中，血管生成素-1与血管生成素-2之间的平衡有利于血管生成素-2。
J Vasc Res. 2008;45(3):244-50. doi: 10.1159/000112939. Epub 2008 Jan 10.
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Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.抗胎盘生长因子可抑制对血管内皮生长因子受体（VEGF(R)）抑制剂耐药的肿瘤生长，且不影响健康血管。
Cell. 2007 Nov 2;131(3):463-75. doi: 10.1016/j.cell.2007.08.038.
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Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization.抗血管生成疗法使动脉粥样硬化斑块血管系统正常化：一种斑块稳定化的潜在策略。
Nat Clin Pract Cardiovasc Med. 2007 Sep;4(9):491-502. doi: 10.1038/ncpcardio0979.
8
Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques.颈动脉斑块不稳定和缺血症状与斑块内微血管发育不成熟有关。
J Vasc Surg. 2007 Jan;45(1):155-9. doi: 10.1016/j.jvs.2006.08.072.
9
Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization.人动脉粥样硬化颈动脉斑块中胎盘生长因子的表达与斑块不稳定有关。
Atherosclerosis. 2008 Jan;196(1):333-340. doi: 10.1016/j.atherosclerosis.2006.10.038. Epub 2006 Dec 8.
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Neovascularization in human atherosclerosis.人类动脉粥样硬化中的新生血管形成。
Circulation. 2006 May 9;113(18):2245-52. doi: 10.1161/CIRCULATIONAHA.105.578955.
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