Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Int J Oral Maxillofac Surg. 2010 Apr;39(4):371-8. doi: 10.1016/j.ijom.2009.12.019. Epub 2010 Feb 2.
Platelet-rich plasma (PRP), containing various growth factors, may speed up wound and bone healing. Using osteoconductive alloplastic materials in reconstructive surgery, the amount of autogenous bone needed can be reduced. The purpose of this experiment was to study the effect of PRP on a mixture of autogenous bone and deproteinized bovine bone mineral (Bio-Oss) particles in goats. Four, round, critical size defects were made in the foreheads of 20 goats. In all goats the defects were filled with a mixture of autogenous particulate cancellous bone and (Bio-Oss) particles, in which 1 ml of PRP was added in two of the four defects. The goats were allocated to four subgroups each containing five goats, which were killed after 1, 2, 6 and 12 weeks. The results of the histological and histomorphometric examination showed that early and late bone healing were not enhanced when PRP was used.
富含血小板的血浆 (PRP) 含有各种生长因子，可能会加速伤口和骨骼愈合。在重建手术中使用骨诱导性同种异体材料，可以减少所需的自体骨量。本实验旨在研究 PRP 对山羊自体骨和脱蛋白牛骨矿物质（Bio-Oss）颗粒混合物的影响。在 20 只山羊的额头上制造了四个圆形、临界大小的缺陷。在所有山羊中，缺陷均用自体颗粒松质骨和（Bio-Oss）颗粒混合物填充，其中四个缺陷中的两个中添加了 1 毫升 PRP。将山羊分为四个亚组，每组包含五只山羊，在 1、2、6 和 12 周后将它们处死。组织学和组织形态计量学检查的结果表明，使用 PRP 并不能促进早期和晚期的骨愈合。
