异柠檬酸脱氢酶 1 基因突变：神经胶质瘤预后和治疗的新范例？
IDH1 gene mutations: a new paradigm in glioma prognosis and therapy?
机构信息
CRICM INSERM UMR 975, Biologie des Interactions Neurones-Glie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
出版信息
Oncologist. 2010;15(2):196-9. doi: 10.1634/theoncologist.2009-0218. Epub 2010 Feb 4.
Abstract
The manuscript examines the role of isocitrate dehydrogenase 1 and the IDH1 gene in the prognosis and therapy of glial tumors.
摘要
该手稿研究了异柠檬酸脱氢酶 1 和 IDH1 基因在神经胶质瘤肿瘤的预后和治疗中的作用。
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本文引用的文献
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.癌症相关的 IDH1 突变会产生 2-羟基戊二酸。
Nature. 2009 Dec 10;462(7274):739-44. doi: 10.1038/nature08617.
2
IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas.异柠檬酸脱氢酶1（IDH1）突变作为继发性胶质母细胞瘤的分子特征和预测因子。
Clin Cancer Res. 2009 Oct 1;15(19):6002-7. doi: 10.1158/1078-0432.CCR-09-0715. Epub 2009 Sep 15.
3
Recurring mutations found by sequencing an acute myeloid leukemia genome.通过对急性髓系白血病基因组进行测序发现的复发性突变。
N Engl J Med. 2009 Sep 10;361(11):1058-66. doi: 10.1056/NEJMoa0903840. Epub 2009 Aug 5.
4
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J Clin Oncol. 2009 Sep 1;27(25):4150-4. doi: 10.1200/JCO.2009.21.9832. Epub 2009 Jul 27.
5
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.人类结肠癌中多肽N-乙酰半乳糖胺基转移酶12的生殖系和体细胞失活突变
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6
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7
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Neuro Oncol. 2009 Aug;11(4):341-7. doi: 10.1215/15228517-2009-025. Epub 2009 May 12.
8
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers.胶质母细胞瘤及其他常见癌症中异柠檬酸脱氢酶1（IDH1）第132位密码子的突变分析。
Int J Cancer. 2009 Jul 15;125(2):353-5. doi: 10.1002/ijc.24379.
9
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.IDH1基因中胶质瘤衍生的突变主要抑制IDH1催化活性并诱导缺氧诱导因子-1α（HIF-1α）。
Science. 2009 Apr 10;324(5924):261-5. doi: 10.1126/science.1170944.
10
Mutations of IDH1 and IDH2 are not detected in brain metastases of colorectal cancer.在结直肠癌脑转移灶中未检测到异柠檬酸脱氢酶1（IDH1）和异柠檬酸脱氢酶2（IDH2）的突变。
J Neurooncol. 2009 Sep;94(2):297. doi: 10.1007/s11060-009-9855-y. Epub 2009 Apr 7.
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