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异柠檬酸脱氢酶 1 基因突变：神经胶质瘤预后和治疗的新范例？

IDH1 gene mutations: a new paradigm in glioma prognosis and therapy?

机构信息

CRICM INSERM UMR 975, Biologie des Interactions Neurones-Glie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

出版信息

Oncologist. 2010;15(2):196-9. doi: 10.1634/theoncologist.2009-0218. Epub 2010 Feb 4.

DOI:10.1634/theoncologist.2009-0218
PMID:20133500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3227941/
Abstract

The manuscript examines the role of isocitrate dehydrogenase 1 and the IDH1 gene in the prognosis and therapy of glial tumors.

摘要

该手稿研究了异柠檬酸脱氢酶 1 和 IDH1 基因在神经胶质瘤肿瘤的预后和治疗中的作用。

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IDH1 gene mutations: a new paradigm in glioma prognosis and therapy?异柠檬酸脱氢酶 1 基因突变：神经胶质瘤预后和治疗的新范例？
Oncologist. 2010;15(2):196-9. doi: 10.1634/theoncologist.2009-0218. Epub 2010 Feb 4.
2
Role of isocitrate dehydrogenase in glioma.异柠檬酸脱氢酶在脑胶质瘤中的作用。
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Isocitrate dehydrogenase mutations in gliomas.胶质瘤中的异柠檬酸脱氢酶突变
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IDH mutations in glioma and acute myeloid leukemia.IDH 突变在胶质瘤和急性髓系白血病中的作用。
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Identification of Prominent Genes between 3D Glioblastoma Models and Clinical Samples via GEO/TCGA/CGGA Data Analysis.通过GEO/TCGA/CGGA数据分析鉴定3D胶质母细胞瘤模型与临床样本之间的显著基因
Biology (Basel). 2023 Apr 25;12(5):648. doi: 10.3390/biology12050648.
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The Multifaceted Glioblastoma: From Genomic Alterations to Metabolic Adaptations.多面性胶质母细胞瘤：从基因组改变到代谢适应。
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本文引用的文献

1
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.癌症相关的 IDH1 突变会产生 2-羟基戊二酸。
Nature. 2009 Dec 10;462(7274):739-44. doi: 10.1038/nature08617.
2
IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas.异柠檬酸脱氢酶1（IDH1）突变作为继发性胶质母细胞瘤的分子特征和预测因子。
Clin Cancer Res. 2009 Oct 1;15(19):6002-7. doi: 10.1158/1078-0432.CCR-09-0715. Epub 2009 Sep 15.
3
Recurring mutations found by sequencing an acute myeloid leukemia genome.通过对急性髓系白血病基因组进行测序发现的复发性突变。
N Engl J Med. 2009 Sep 10;361(11):1058-66. doi: 10.1056/NEJMoa0903840. Epub 2009 Aug 5.
4
Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.异柠檬酸脱氢酶1第132位密码子突变是神经胶质瘤中一种重要的预后生物标志物。
J Clin Oncol. 2009 Sep 1;27(25):4150-4. doi: 10.1200/JCO.2009.21.9832. Epub 2009 Jul 27.
5
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.人类结肠癌中多肽N-乙酰半乳糖胺基转移酶12的生殖系和体细胞失活突变
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12921-5. doi: 10.1073/pnas.0901454106. Epub 2009 Jul 17.
6
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.IDH1和IDH2突变的类型及频率与星形胶质细胞和少突胶质细胞分化及年龄相关：一项对1010例弥漫性胶质瘤的研究
Acta Neuropathol. 2009 Oct;118(4):469-74. doi: 10.1007/s00401-009-0561-9. Epub 2009 Jun 25.
7
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.异柠檬酸脱氢酶1（IDH1）突变存在于大多数常见的成人胶质瘤中，但在原发性胶质母细胞瘤中罕见。
Neuro Oncol. 2009 Aug;11(4):341-7. doi: 10.1215/15228517-2009-025. Epub 2009 May 12.
8
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers.胶质母细胞瘤及其他常见癌症中异柠檬酸脱氢酶1（IDH1）第132位密码子的突变分析。
Int J Cancer. 2009 Jul 15;125(2):353-5. doi: 10.1002/ijc.24379.
9
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.IDH1基因中胶质瘤衍生的突变主要抑制IDH1催化活性并诱导缺氧诱导因子-1α（HIF-1α）。
Science. 2009 Apr 10;324(5924):261-5. doi: 10.1126/science.1170944.
10
Mutations of IDH1 and IDH2 are not detected in brain metastases of colorectal cancer.在结直肠癌脑转移灶中未检测到异柠檬酸脱氢酶1（IDH1）和异柠檬酸脱氢酶2（IDH2）的突变。
J Neurooncol. 2009 Sep;94(2):297. doi: 10.1007/s11060-009-9855-y. Epub 2009 Apr 7.