Laboratoire des Interactions Plantes Micro-organismes, Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, 31326 Castanet Tolosan cedex, France.
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2343-8. doi: 10.1073/pnas.0913320107. Epub 2010 Jan 19.
Remorin proteins have been hypothesized to play important roles during cellular signal transduction processes. Induction of some members of this multigene family has been reported during biotic interactions. However, no roles during host-bacteria interactions have been assigned to remorin proteins until now. We used root nodule symbiosis between Medicago truncatula and Sinorhizobium meliloti to study the roles of a remorin that is specifically induced during nodulation. Here we show that this oligomeric remorin protein attaches to the host plasma membrane surrounding the bacteria and controls infection and release of rhizobia into the host cytoplasm. It interacts with the core set of symbiotic receptors that are essential for perception of bacterial signaling molecules, and thus might represent a plant-specific scaffolding protein.
Remorin 蛋白被假设在细胞信号转导过程中发挥重要作用。该多基因家族的一些成员在生物相互作用中被诱导。然而，直到现在，Remorin 蛋白在宿主-细菌相互作用中的作用还没有被确定。我们利用紫花苜蓿和根瘤菌之间的根瘤共生关系来研究在结瘤过程中特异性诱导的 Remorin 的作用。在这里，我们表明这种寡聚 Remorin 蛋白附着在围绕细菌的宿主质膜上，并控制感染和根瘤菌释放到宿主细胞质中。它与共生受体的核心组相互作用，这些受体对于感知细菌信号分子是必不可少的，因此可能代表一种植物特异性支架蛋白。
