Mizukami Y, Nonomura A, Hashimoto T, Michigishi T, Noguchi M, Matsubara F, Yanaihara N
Pathology Section, Kanazawa University Hospital, Japan.
Histopathology. 1991 Jan;18(1):11-8. doi: 10.1111/j.1365-2559.1991.tb00808.x.
The expression of epidermal growth factor (EGF) and c-myc oncogene product was studied immunohistochemically in 65 benign and malignant human thyroids. Normal thyroid tissues were usually negative with each antibody. Benign and malignant neoplastic thyroid tissues demonstrated a high percentage of stained cells. However, there was no significant difference in positivity between benign and malignant neoplastic tissues. In Graves' disease 25% of the cases were positive for EGF, and 100% for c-myc product. The effect of EGF or c-myc expression on prognosis was also examined in 42 patients with papillary thyroid carcinoma. When the cases were divided into two groups with regard to their EGF staining score (highly-expressed and poorly-expressed groups), the frequency of highly-expressed tumours was significantly higher in the recurrence-positive group compared with the recurrence-free group (86% vs 57%), but there was no significant difference between the groups in respect of c-myc expression.
采用免疫组织化学方法研究了65例人甲状腺良恶性病变组织中表皮生长因子（EGF）及c-myc癌基因产物的表达情况。正常甲状腺组织通常对两种抗体均呈阴性反应。甲状腺良恶性肿瘤组织均显示出较高比例的染色细胞。然而，良性和恶性肿瘤组织之间的阳性率无显著差异。在格雷夫斯病中，25%的病例EGF呈阳性，100%的病例c-myc产物呈阳性。对42例甲状腺乳头状癌患者，还研究了EGF或c-myc表达对预后的影响。当根据EGF染色评分将病例分为两组（高表达组和低表达组）时，复发阳性组中高表达肿瘤的发生率显著高于无复发组（86%对57%），但两组之间c-myc表达无显著差异。
