Laboratory of Clinical Psychopharmacology, Beijing Anding Hospital, Capital Medical University, Xicheng District, 100088, Beijing, China.
Qual Life Res. 2010 Apr;19(3):317-22. doi: 10.1007/s11136-010-9593-9. Epub 2010 Feb 5.
The aim of the study was to assess the changes in the quality of life (QOL) of Chinese schizophrenia patients and to identify their predictors over a 1-year follow-up.
A cohort of 116 schizophrenia patients was recruited, and their socio-demographic and clinical characteristics including psychotic and depressive symptoms, drug-induced side effects, social functioning, and QOL were assessed with standardized rating instruments. The patients received standard psychiatric care and were followed up for 1 year.
The psychotic and depressive symptoms, extrapyramidal side effects, and QOL domains of physical functioning, role limitations due to physical problems, social functioning, and role limitations due to emotional problems all improved significantly. Social functioning was a predictor of baseline QOL and change at 1-year follow-up.
Routine clinical management was effective in improving schizophrenia patients' psychopathology and several domains of QOL. QOL was related to the level of social functioning and had only a weak association with socio-demographic factors.
本研究旨在评估中国精神分裂症患者在 1 年随访期间生活质量（QOL）的变化，并确定其预测因素。
招募了 116 例精神分裂症患者，采用标准化评定工具评估其社会人口学和临床特征，包括精神病性和抑郁症状、药物引起的副作用、社会功能和 QOL。患者接受标准精神科治疗，并随访 1 年。
精神病性和抑郁症状、锥体外系副作用以及身体功能、因身体问题导致的角色限制、社会功能和因情绪问题导致的角色限制等 QOL 领域均显著改善。社会功能是基线 QOL 和 1 年随访时变化的预测因素。
常规临床管理可有效改善精神分裂症患者的精神病理学和多个 QOL 领域。QOL 与社会功能水平相关，与社会人口学因素仅存在微弱关联。
