Department of Microbiology, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Curr Opin Immunol. 2010 Feb;22(1):4-9. doi: 10.1016/j.coi.2010.01.007.
The study of Drosophila, and other genetically tractable insects, has expanded our understanding of innate immunity and more recently antiviral innate mechanisms. The Drosophila antiviral program includes inflammatory signaling cascades as well as antiviral RNA silencing and autophagy. This review will highlight the recent discoveries in antiviral immunity in insects and will reveal some of the lessons learned.
Drosophila 的研究，以及其他遗传上易于操作的昆虫，扩展了我们对先天免疫的理解，最近也扩展了抗病毒先天机制的理解。果蝇抗病毒程序包括炎症信号级联反应，以及抗病毒 RNA 沉默和自噬。这篇综述将重点介绍昆虫抗病毒免疫的最新发现，并揭示一些从中获得的经验教训。
