Lamiable Olivier, Imler Jean-Luc
CNRS-UPR9022, Institut de Biologie Moléculaire et Cellulaire, 15 rue Descartes, F-67084 Strasbourg, France.
CNRS-UPR9022, Institut de Biologie Moléculaire et Cellulaire, 15 rue Descartes, F-67084 Strasbourg, France; Faculté des Sciences de la Vie, Université de Strasbourg, 28 rue Goethe, F-67083 Strasbourg, France.
Curr Opin Microbiol. 2014 Aug;20:62-8. doi: 10.1016/j.mib.2014.05.006. Epub 2014 Jun 5.
Immunity to viral infections in the model organism Drosophila melanogaster involves both RNA interference and additional induced responses. The latter include not only cellular mechanisms such as programmed cell death and autophagy, but also the induction of a large set of genes, some of which contribute to the control of viral replication and resistance to infection. This induced response to infection is complex and involves both virus-specific and cell-type specific mechanisms. We review here recent developments, from the sensing of viral infection to the induction of signaling pathways and production of antiviral effector molecules. Our current understanding, although still partial, validates the Drosophila model of antiviral induced immunity for insect pests and disease vectors, as well as for mammals.
模式生物黑腹果蝇对病毒感染的免疫涉及RNA干扰和其他诱导反应。后者不仅包括程序性细胞死亡和自噬等细胞机制，还包括大量基因的诱导，其中一些基因有助于控制病毒复制和抵抗感染。这种对感染的诱导反应很复杂，涉及病毒特异性和细胞类型特异性机制。我们在此回顾从病毒感染的感知到信号通路的诱导以及抗病毒效应分子产生的最新进展。我们目前的理解虽然仍然不完整，但证实了果蝇抗病毒诱导免疫模型对害虫和疾病媒介以及哺乳动物的有效性。
