Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
Indian J Pediatr. 2010 May;77(5):565-6. doi: 10.1007/s12098-010-0019-z. Epub 2010 Feb 8.
Presented here is a report of 3 children, out of 66 total pediatric Hodgkin's lymphoma (HL) patients (4.5%) with bone involvement over a 3 and a half year period. Two patients presented with osseous lesions at the time of relapse and one had concurrent evidence of non-osseous disease. The clinical presentation, radiographic findings, histology, treatment and outcome of these patients are discussed. Boys and girls are nearly equally affected, local bone pain is the commonest symptom and B-symptoms are common. Vertebrae and pelvis are most frequently involved, commonly with an osteolytic picture. Nodular sclerosis is the predominant histological subtype. Most children received combined modality treatment and the overall response and survival are good.
现报告 3 例儿童患者，均为在 3.5 年期间的 66 例儿童霍奇金淋巴瘤（HL）患者（4.5%）中有骨骼受累。2 例患者在复发时出现骨病变，1 例患者同时有非骨骼疾病的证据。讨论了这些患者的临床表现、影像学发现、组织学、治疗和结果。男孩和女孩受影响的比例几乎相等，常见的症状是局部骨痛和 B 症状常见。最常受累的部位是椎体和骨盆，通常表现为溶骨性。结节性硬化是最主要的组织学亚型。大多数儿童接受联合治疗，整体反应和生存情况良好。
