转化生长因子β1对培养的子宫上皮细胞凋亡和细胞增殖的协同调节作用
Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.
作者信息
Rotello R J, Lieberman R C, Purchio A F, Gerschenson L E
机构信息
Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.
出版信息
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3412-5. doi: 10.1073/pnas.88.8.3412.
Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.
细胞和组织的生长是通过刺激信号和抑制信号之间复杂的相互作用来调节的。我们描述了转化生长因子β1（TGF-β1）在兔子宫上皮细胞原代培养中的两种生物学作用：（i）抑制细胞增殖，以及（ii）同时增加正在经历凋亡（程序性细胞死亡）的细胞数量。有人提出，增殖和凋亡共同构成正常的细胞生长调节。
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