Unité de Chimie et de Physique des Hauts Polymères, Université catholique de Louvain, Croix du Sud 1, 1348, Louvain-la-Neuve, Belgium.
J Mater Sci Mater Med. 2010 Mar;21(3):925-30. doi: 10.1007/s10856-010-4008-6. Epub 2010 Feb 9.
One of the key challenges to engineering neural interfaces is to reduce their immune response toward implanted electrodes. One potential approach to minimize or eliminate this undesired early inflammatory tissue reaction and to maintain signal transmission quality over time is the delivery of anti-inflammatory biomolecules in the vicinity of the implant. Here, we report on a facile and reproducible method for the fabrication of high surface area nanostructured electrodes coated with an electroactive polymer, polypyrrole (PPy) that can be used to precisely release drug by applying an electrical stimuli. The method consists of the electropolymerization of PPy incorporated with drug, dexamethasone (DEX), onto a brush of metallic nanopillars, obtained by electrodeposition of the metal within the nanopores of gold-coated polycarbonate template. The study of the release of DEX triggered by electrochemical stimuli indicates that the system is a true electrically controlled release system. Moreover, it appears that the presence of metallic nanowires onto the electrode surface improves the adherence between the polymer and the electrode and increases the electroactivity of the PPy coating.
工程化神经接口的主要挑战之一是降低其对植入电极的免疫反应。一种潜在的方法是减少或消除这种不理想的早期炎症组织反应，并随着时间的推移保持信号传输质量，即在植入物附近输送抗炎生物分子。在这里，我们报告了一种简便且可重复的方法，用于制造具有高表面积的纳米结构电极，该电极涂有聚吡咯（PPy），通过施加电刺激可以精确释放药物。该方法包括将药物地塞米松（DEX）掺入到通过在金涂覆的聚碳酸酯模板的纳米孔内电沉积金属而获得的金属纳米柱刷上进行电聚合 PPy。通过电化学刺激触发的 DEX 释放研究表明，该系统是一种真正的电控制释放系统。此外，似乎电极表面上存在金属纳米线可以提高聚合物和电极之间的粘附力，并增加 PPy 涂层的电活性。
