Jia Lin, Jiang Shu-Man, Shang Yuan-Yuan, Huang Yao-Xing, Li Yi-Jun, Xie De-Rong, Huang Kai-Hong, Zhi Fa-Cao
Department of Gastroenterology, Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College, Guangzhou, China.
Digestion. 2010;82(1):4-9. doi: 10.1159/000253864. Epub 2010 Feb 9.
To investigate the incidence of pancreatic cancer-related depression and the relationship between symptoms of depression and the quality of life (QoL) of patients.
262 inpatients with cancer of the digestive system (pancreatic cancer, liver cancer, esophageal cancer, gastric cancer, and colorectal cancer) from four Guangzhou hospitals were enrolled into the study between June 2007 and June 2009. The Hamilton Rating Scale for Depression-24 questionnaire was used to assess the degree of depression. QoL of all patients was evaluated by EORTC QLQ-C30. Additionally, EORTC QLQ-PAN-26 was used for patients with pancreatic cancer.
The incidence of depression among pancreatic cancer patients was significantly higher than among other digestive cancers. More pancreatic cancer patients suffered severe depression than those with liver cancer and gastric cancer. Compared with other groups with depression, QoL of pancreatic cancer patients in each functioning scale was significantly worse, while the symptoms of fatigue and pain were significantly severe. QoL of pancreatic cancer patients with depression in role, emotional, and social functioning were sharply poorer than those without depression. The symptoms of fatigue, pain and appetite loss in cancer patients with depression were significantly more frequent than those without depression.
Compared with other cancers of the digestive system, depressive symptoms are common psychological disturbances in pancreatic cancer patients. Moreover, depression significantly lowers QoL in pancreatic cancer patients.
调查胰腺癌相关抑郁的发生率以及抑郁症状与患者生活质量（QoL）之间的关系。
2007年6月至2009年6月期间，来自广州四家医院的262例消化系统癌症（胰腺癌、肝癌、食管癌、胃癌和结直肠癌）住院患者被纳入研究。采用汉密尔顿抑郁评定量表-24问卷评估抑郁程度。所有患者的生活质量通过欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）进行评估。此外，EORTC QLQ-PAN-26用于胰腺癌患者。
胰腺癌患者的抑郁发生率显著高于其他消化系统癌症患者。与肝癌和胃癌患者相比，更多胰腺癌患者患有严重抑郁。与其他抑郁组相比，胰腺癌患者在各个功能量表上的生活质量明显更差，而疲劳和疼痛症状明显更严重。有抑郁的胰腺癌患者在角色、情感和社会功能方面的生活质量比无抑郁的患者明显更差。有抑郁的癌症患者的疲劳、疼痛和食欲减退症状比无抑郁的患者明显更频繁。
与其他消化系统癌症相比，抑郁症状是胰腺癌患者常见的心理障碍。此外，抑郁显著降低了胰腺癌患者的生活质量。
