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结核分枝杆菌 IS6110 插入的新热点。

Novel hot spot of IS6110 insertion in Mycobacterium tuberculosis.

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, Francis J Curry National Tuberculosis Center, University of California, San Francisco, California, USA.

出版信息

J Clin Microbiol. 2010 Apr;48(4):1422-4. doi: 10.1128/JCM.02210-09. Epub 2010 Feb 10.

DOI:10.1128/JCM.02210-09
PMID:20147648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2849554/
Abstract

We describe a hot spot for the insertion of IS6110 in Mycobacterium tuberculosis located in the area of region of difference 724 (RD724). Because RD724 defines sublineage 724 of M. tuberculosis, caution must be exercised when screening for RD724, as different polymorphisms can be observed in this region.

摘要

我们描述了结核分枝杆菌中插入 IS6110 的热点位于差异区 724（RD724）的区域。由于 RD724 定义了结核分枝杆菌的亚谱系 724，因此在筛选 RD724 时必须谨慎，因为在此区域可以观察到不同的多态性。

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本文引用的文献

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High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography.由基因漂变和人类人口统计学驱动的结核分枝杆菌高度功能多样性。
PLoS Biol. 2008 Dec 16;6(12):e311. doi: 10.1371/journal.pbio.0060311.
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Mycobacterium tuberculosis Uganda genotype is the predominant cause of TB in Kampala, Uganda.乌干达结核分枝杆菌基因型是乌干达坎帕拉结核病的主要病因。
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The role of IS6110 in the evolution of Mycobacterium tuberculosis.IS6110在结核分枝杆菌进化中的作用。
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Molecular epidemiology of tuberculosis: current insights.结核病的分子流行病学：当前见解
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A genomic library-based amplification approach (GL-PCR) for the mapping of multiple IS6110 insertion sites and strain differentiation of Mycobacterium tuberculosis.一种基于基因组文库的扩增方法（GL-PCR），用于结核分枝杆菌多个IS6110插入位点的定位及菌株鉴别。
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Moxifloxacin versus ethambutol in the first 2 months of treatment for pulmonary tuberculosis.莫西沙星与乙胺丁醇用于肺结核治疗前两个月的疗效比较
Am J Respir Crit Care Med. 2006 Aug 1;174(3):331-8. doi: 10.1164/rccm.200603-360OC. Epub 2006 May 4.
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