合成一种灵敏且选择性的钾离子荧光探针。
Synthesis of a sensitive and selective potassium-sensing fluoroionophore.
机构信息
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California, USA.
出版信息
Org Lett. 2010 Mar 19;12(6):1160-3. doi: 10.1021/ol902836c.
Abstract
An efficient synthesis is reported that delivers in 5 steps and 52% overall yield a new structurally simplified fluorescent K(+) sensor with improved K(+) sensitivity and selectivity over existing K(+) sensors. The synthesis procedure utilizes a new template-directed oxidative C-N bond-forming macrocyclization reaction and reports new approaches to Pd(0), Sandmeyer-like and metal-free aminoarylations, as well as organotitanium additions to vinylogous sulfonates.
摘要
报告了一种高效的合成方法，通过 5 步反应以 52%的总产率得到了一种新的结构简化的荧光 K(+)传感器，与现有的 K(+)传感器相比，该传感器具有更高的 K(+)灵敏度和选择性。该合成方法利用了一种新的模板导向的氧化 C-N 键形成大环化反应，并报告了钯(0)、Sandmeyer 型和无金属芳基化以及有机钛对烯醇式砜的加成的新方法。
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