病毒粒子成熟：对精巧编程纳米机器的深入了解。
Virus particle maturation: insights into elegantly programmed nanomachines.
机构信息
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Curr Opin Struct Biol. 2010 Apr;20(2):210-6. doi: 10.1016/j.sbi.2010.01.004. Epub 2010 Feb 9.
Abstract
Similar modes of virus maturation have been observed in dsDNA bacteriophages and the structurally related herpes viruses and some type of maturation occur in most animal viruses. Recently a variety of biophysical studies of maturation intermediates of bacteriophages P22, lambda, and HK97 have suggested an energy landscape that drives the transitions and structure-based mechanisms for its formation. Near-atomic resolution models of subunit tertiary structures in an early intermediate of bacteriophage HK97 maturation revealed a remarkable distortion of the secondary structures when compared to the mature particle. Scaffolding proteins may induce the distortion that is maintained by quaternary structure interactions following scaffold release, making the intermediate particle metastable.
摘要
在双链 DNA 噬菌体和结构相关的疱疹病毒中观察到类似的病毒成熟模式，并且在大多数动物病毒中也存在某种形式的成熟。最近，对噬菌体 P22、lambda 和 HK97 成熟中间产物的多种生物物理研究表明，存在一种能量景观驱动着这些转变，并且存在基于结构的形成机制。在噬菌体 HK97 成熟的早期中间产物的亚基三级结构的近原子分辨率模型中，与成熟颗粒相比，二级结构发生了显著的扭曲。支架蛋白可能会诱导这种扭曲，而在支架释放后，四级结构相互作用会维持这种扭曲，使中间产物处于亚稳态。
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