Public Health Research Unit, Department of Psychiatry and Psychotherapy, Department of Mental Health, University of Leipzig, Leipzig, Germany.
Dement Geriatr Cogn Disord. 2010;29(2):164-75. doi: 10.1159/000272424. Epub 2010 Feb 11.
BACKGROUND/AIMS: Subjects with mild cognitive impairment (MCI) constitute a risk population of developing dementia and thus a population of clinical interest. This study reviews recent work on the incidence of MCI in the elderly.
Incidence papers were identified by a systematic literature search. Studies on the incidence of MCI were considered if they identified 'cognitively mildly impaired' subjects by application of the MCI criteria, used the 'person-years-at-risk' method, and were based on population- or community-based samples.
Nine studies were identified. The incidence of amnestic MCI subtypes ranged between 9.9 and 40.6 per 1,000 person-years, and the incidence of non-amnestic MCI subtypes was 28 and 36.3 per 1,000 person-years. Regarding any MCI, incidence rates of 51 and 76.8 per 1,000 person-years were found. A higher risk of incident MCI mainly resulted for higher age, lower education and hypertension.
The incidence rates of MCI varied widely, and possible risk factors for incident MCI were analysed only to a limited extent. The findings call for an agreement concerning the criteria used for MCI and the operationalisation of these criteria.
背景/目的：轻度认知障碍（MCI）患者是发展为痴呆的高危人群，因此也是临床关注的人群。本研究综述了老年人 MCI 发病率的最新研究。
通过系统文献检索确定发病率研究。如果研究通过应用 MCI 标准确定“认知轻度受损”的受试者、使用“风险人群年”方法且基于人群或社区样本，则被认为是 MCI 发病率研究。
确定了 9 项研究。遗忘型 MCI 亚型的发病率在每 1000 人年 9.9 至 40.6 例之间，非遗忘型 MCI 亚型的发病率为每 1000 人年 28 至 36.3 例。对于任何 MCI，发病率为每 1000 人年 51 至 76.8 例。MCI 发病风险主要与较高的年龄、较低的教育程度和高血压有关。
MCI 的发病率差异很大，对 MCI 的可能危险因素的分析也很有限。这些发现呼吁就 MCI 使用的标准和这些标准的操作达成一致。
