Sicard Kenneth M, Fisher Marc
Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01453, USA.
Exp Transl Stroke Med. 2009 Nov 13;1:7. doi: 10.1186/2040-7378-1-7.
Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology of ischemic injury and developing therapies is an important endeavor that requires much additional research. Animal stroke models provide an important mechanism for these activities. A large number of stroke models have been developed and are currently used in laboratories around the world. These models are overviewed as are approaches for measuring infarct size and functional outcome.
在许多国家，中风是导致残疾和死亡的主要原因。了解缺血性损伤的病理生理学并开发相应疗法是一项重要工作，这需要更多的研究。动物中风模型为这些研究活动提供了重要机制。目前已开发出大量中风模型并在世界各地的实验室中使用。本文将对这些模型以及测量梗死面积和功能转归的方法进行综述。
