局灶性脑缺血的动物模型
Animal models of focal brain ischemia.
作者信息
Sicard Kenneth M, Fisher Marc
机构信息
Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01453, USA.
出版信息
Exp Transl Stroke Med. 2009 Nov 13;1:7. doi: 10.1186/2040-7378-1-7.
Abstract
Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology of ischemic injury and developing therapies is an important endeavor that requires much additional research. Animal stroke models provide an important mechanism for these activities. A large number of stroke models have been developed and are currently used in laboratories around the world. These models are overviewed as are approaches for measuring infarct size and functional outcome.
摘要
在许多国家，中风是导致残疾和死亡的主要原因。了解缺血性损伤的病理生理学并开发相应疗法是一项重要工作，这需要更多的研究。动物中风模型为这些研究活动提供了重要机制。目前已开发出大量中风模型并在世界各地的实验室中使用。本文将对这些模型以及测量梗死面积和功能转归的方法进行综述。
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本文引用的文献
1
Animal models of ischemic stroke.
Handb Clin Neurol. 2009;92:43-66. doi: 10.1016/S0072-9752(08)01903-9.
2
Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials.急性卒中神经保护的未来：圣 trials 试验之后
Ann Neurol. 2007 May;61(5):396-402. doi: 10.1002/ana.21127.
3
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats.惊人的缩小的缺损：来自斯普拉格-道利大鼠大脑中动脉栓塞闭塞后多模态磁共振成像的见解。
J Cereb Blood Flow Metab. 2007 Oct;27(10):1756-63. doi: 10.1038/sj.jcbfm.9600477. Epub 2007 Mar 21.
4
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats.大鼠短暂性局灶性脑缺血后基于功能磁共振成像的脑功能、行为状态及组织病理学的长期变化
Stroke. 2006 Oct;37(10):2593-600. doi: 10.1161/01.STR.0000239667.15532.c1. Epub 2006 Aug 31.
5
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats.大鼠短暂性局灶性脑缺血后多模态磁共振成像与行为的差异恢复
J Cereb Blood Flow Metab. 2006 Nov;26(11):1451-62. doi: 10.1038/sj.jcbfm.9600299. Epub 2006 Mar 15.
6
Characterization of a novel chronic photothrombotic ring stroke model in rats by magnetic resonance imaging, biochemical imaging, and histology.通过磁共振成像、生化成像和组织学对大鼠新型慢性光血栓性环形卒中模型进行表征。
J Cereb Blood Flow Metab. 2004 Jul;24(7):789-97. doi: 10.1097/01.WCB.0000123905.17746.DB.
7
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia.表征实验性局灶性脑缺血中的扩散/灌注不匹配
Ann Neurol. 2004 Feb;55(2):207-12. doi: 10.1002/ana.10803.
8
Incomplete assessment of experimental cytoprotectants in rodent ischemia studies.啮齿动物缺血研究中实验性细胞保护剂的评估不完整。
Can J Neurol Sci. 2003 Nov;30(4):368-74. doi: 10.1017/s0317167100003097.
9
Studies in cerebrovascular disease. VII. Experimental production of cerebral infarction by intracarotid injection of homologous blood clot; preliminary report.
Proc Staff Meet Mayo Clin. 1955 Dec 28;30(26):625-33.
10
Evaluation of MCAO stroke models in normotensive rats: standardized neocortical infarction by the 3VO technique.正常血压大鼠大脑中动脉闭塞性卒中模型的评估：采用三血管闭塞技术实现标准化的新皮质梗死
Exp Neurol. 2003 Aug;182(2):261-74. doi: 10.1016/s0014-4886(03)00116-x.
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