State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Chem Biodivers. 2010 Feb;7(2):383-91. doi: 10.1002/cbdv.200800313.
Panax notoginseng and Carthamus tinctorius are known as traditional medicinal plants, and they also have edible values. To better understand their pharmacological mechanism, the present study assessed the in vitro antioxidant activities of extracts of P. notoginseng (EPN) and C. tinctorius (ECT). In addition, the main components of EPN and ECT were determined by HPLC. The results show that EPN mainly contained saponins, which were effective in scavenging (.)OH and O(.)(2-), while showing a low activity in the DPPH(.) assay. Flavonoids were the main components of ECT and were active in scavenging all three radicals in a dose-dependent manner. In brief, the antioxidant properties of EPN and ECT are distinct and might be complementary, their combined use tending to be more effective in scavenging (.)OH (P<0.05 vs. EPN or ECT).
三七和红花是众所周知的药用植物，它们也具有食用价值。为了更好地了解它们的药理机制，本研究评估了三七提取物（EPN）和红花提取物（ECT）的体外抗氧化活性。此外，还通过 HPLC 确定了 EPN 和 ECT 的主要成分。结果表明，EPN 主要含有皂苷，对（·）OH 和 O（·）（2-）的清除效果显著，而对 DPPH（·）的清除活性较低。黄酮类化合物是 ECT 的主要成分，对三种自由基的清除活性均呈剂量依赖性。总之，EPN 和 ECT 的抗氧化特性明显不同，可能具有互补性，联合使用在清除（·）OH 方面更为有效（P<0.05 比 EPN 或 ECT）。
