Wu-Williams A H, Lee M, Whittemore A S, Gallagher R P, Jiao D A, Zheng S, Zhou L, Wang X H, Chen K, Jung D
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033-9987.
Cancer Res. 1991 May 1;51(9):2307-11.
We report results from a population-based case-control study of colorectal cancer among Chinese women in western North America (NA) and the People's Republic of China (China). A common protocol was used to assess reproductive characteristics and hormone use of 395 Chinese women (189 from NA and 206 from China) with cancer of the colon or rectum and of 1112 age-matched Chinese controls (494 from NA and 618 from China). In NA, risks for cancers of both the colon and rectum were lower among parous compared to nulliparous women (odds ratio for colorectal cancer, 0.6, P = 0.08), but the trend in risk was not smooth with increasing number of livebirths. This association with parity was absent for both cancer sites in China. There were no consistent patterns in the relationships between other reproductive factors (including age at menarche, age at first livebirth, menopausal status) and risk of colon and rectal cancer on either continent.
我们报告了一项针对北美西部和中华人民共和国（中国）华裔女性的基于人群的结直肠癌病例对照研究结果。采用通用方案评估了395名患有结肠癌或直肠癌的华裔女性（189名来自北美，206名来自中国）以及1112名年龄匹配的华裔对照者（494名来自北美，618名来自中国）的生殖特征和激素使用情况。在北美，经产妇患结肠癌和直肠癌的风险均低于未产妇（结直肠癌的比值比为0.6，P = 0.08），但随着活产数增加，风险趋势并不平滑。在中国，这两个癌症部位与产次均无关联。在这两个大陆上，其他生殖因素（包括初潮年龄、首次活产年龄、绝经状态）与结肠癌和直肠癌风险之间均无一致的模式。
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