Role of NFkappaB in age-related vascular endothelial dysfunction in humans.
作者信息
Donato Anthony J, Pierce Gary L, Lesniewski Lisa A, Seals Douglas R
机构信息
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
出版信息
Aging (Albany NY). 2009 Aug 10;1(8):678-80. doi: 10.18632/aging.100080.
Abstract
摘要
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Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.在超重/肥胖的中老年人中，核因子-κB激活通过氧化应激导致血管内皮功能障碍。
Circulation. 2009 Mar 10;119(9):1284-92. doi: 10.1161/CIRCULATIONAHA.108.804294. Epub 2009 Feb 23.
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Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans.衰老与健康人体血管内皮细胞中更高水平的核因子κB、降低的IκBα以及促炎细胞因子表达增加有关。
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Inflammatory mediators in the elderly.老年人中的炎症介质。
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