Cladel Nancy M, Bertotto Alex, Christensen Neil D
Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Virus Genes. 2010 Jun;40(3):329-40. doi: 10.1007/s11262-010-0451-1. Epub 2010 Feb 16.
Human papillomaviruses use rare codons relative to their hosts. It has been theorized that this is a mechanism to allow the virus to escape immune surveillance. In the present study, we examined the codings of four major genes of 21 human alpha (mucosatropic) viruses and 16 human beta (cutaneous-tropic) viruses. We compared the codon usage of different genes from a given papillomavirus and also the same genes from different papillomaviruses. Our data showed that codon usage was not always uniform between two genes of a given papillomavirus or between the same genes of papillomaviruses from different genera. We speculate as to why this might be and conclude that codon usage in the papillomaviruses may not only play a role in facilitating escape from immune surveillance but may also underlie some of the unanswered questions in the papillomavirus field.
相对于其宿主而言，人乳头瘤病毒使用稀有密码子。从理论上来说，这是一种使病毒逃避免疫监视的机制。在本研究中，我们检测了21种人α（嗜黏膜）病毒和16种人β（嗜皮肤）病毒的四个主要基因的编码情况。我们比较了来自给定乳头瘤病毒的不同基因以及来自不同乳头瘤病毒的相同基因的密码子使用情况。我们的数据表明，在给定乳头瘤病毒的两个基因之间或来自不同属的乳头瘤病毒的相同基因之间，密码子使用情况并不总是一致的。我们推测了其中的原因，并得出结论，乳头瘤病毒中的密码子使用情况可能不仅在促进逃避免疫监视方面发挥作用，还可能是乳头瘤病毒领域中一些未解决问题的基础。
