Taylor C A, Humphrey J D
Departments of Bioengineering and Surgery, Stanford University, Stanford, CA, USA,
Comput Methods Appl Mech Eng. 2009 Sep 15;198(45-46):3514-3523. doi: 10.1016/j.cma.2009.02.004.
The vasculature consists of a complex network of vessels ranging from large arteries to arterioles, capillaries, venules, and veins. This network is vital for the supply of oxygen and nutrients to tissues and the removal of carbon dioxide and waste products from tissues. Because of its primary role as a pressure-driven chemomechanical transport system, it should not be surprising that mechanics plays a vital role in the development and maintenance of the normal vasculature as well as in the progression and treatment of vascular disease. This review highlights some past successes of vascular biomechanics, but emphasizes the need for research that synthesizes complementary advances in molecular biology, biomechanics, medical imaging, computational methods, and computing power for purposes of increasing our understanding of vascular physiology and pathophysiology as well as improving the design of medical devices and clinical interventions, including surgical procedures. That is, computational mechanics has great promise to contribute to the continued improvement of vascular health.
脉管系统由一个复杂的血管网络组成，范围从大动脉到小动脉、毛细血管、小静脉和静脉。这个网络对于向组织供应氧气和营养物质以及从组织中清除二氧化碳和废物至关重要。由于其作为压力驱动的化学机械运输系统的主要作用，力学在正常脉管系统的发育和维持以及血管疾病的进展和治疗中发挥至关重要的作用也就不足为奇了。本综述强调了血管生物力学过去的一些成功，但强调需要开展研究，综合分子生物学、生物力学、医学成像、计算方法和计算能力等方面的互补进展，以增进我们对血管生理学和病理生理学的理解，并改进医疗设备的设计和临床干预措施，包括外科手术。也就是说，计算力学有望为血管健康的持续改善做出贡献。
