Fu Tsung-Hao, Bonaparte Amy, Martin Stephen F
Department of Chemistry and Biochemistry, The University of Texas, Austin, TX USA 78712.
Tetrahedron Lett. 2009 Jul 1;50(26):3253-3257. doi: 10.1016/j.tetlet.2009.02.018.
A variety of heterocyclic alcohols and acetates were coupled with silyl ketene acetals and other π-nucleophiles in the presence of trimethylsilyl trifluoromethanesulfonate to provide an array of substituted β-heteroaryl propionates, including those with contiguous quaternary centers, as well as vinylogs thereof. This reaction also proceeds with high diastereoselectivity when the π-nucleophile bears a chiral auxiliary.
在三甲基甲硅烷基三氟甲磺酸酯存在下，多种杂环醇和乙酸酯与甲硅烷基烯酮缩醛及其他π-亲核试剂偶联，以提供一系列取代的β-杂芳基丙酸酯，包括具有相邻季碳中心的那些，以及它们的插烯物。当π-亲核试剂带有手性助剂时，该反应也以高非对映选择性进行。
