Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Org Lett. 2010 Jun 4;12(11):2492-5. doi: 10.1021/ol1006373.
The synthesis of a functionalized, tetracyclic core of N-methylwelwitindolinone C isothiocyanate is reported. The approach features a convergent coupling between an indole iminium ion and a highly functionalized vinylogous silyl ketene acetal followed by an intramolecular palladium-catalyzed cyclization that proceeds via an enolate arylation.
本文报道了 N-甲基威尔维啶酮 C 异硫氰酸酯的功能化四环核心的合成。该方法的特点是吲哚亚胺离子与高度功能化的乙烯基硅基酮缩醛之间的收敛偶联,然后通过烯醇化物芳基化进行钯催化的分子内环化。