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穿心莲内酯对TD - 47人乳腺癌细胞系的凋亡诱导作用。

Apoptosis inducing effect of andrographolide on TD-47 human breast cancer cell line.

作者信息

Sukardiman Harjotaruno, Widyawaruyanti Aty, Zaini Noor Cholies

机构信息

Department of Natural Product Sciences, Faculty of Pharmacy Airlangga University, Surabaya, Indonesia.

出版信息

Afr J Tradit Complement Altern Med. 2007 Feb 16;4(3):345-51. doi: 10.4314/ajtcam.v4i3.31228.

DOI:10.4314/ajtcam.v4i3.31228
PMID:20161898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2816486/
Abstract

Andrographolide isolated from Andrographis paniculata Ness (Acanthaceae) at 0.35 mM, 0.70 mM and 1.40 mM induced DNA fragmentation and increased the percentage of apoptotic cells when TD-47 human breast cancer cell line was treated for 24, 48 and 72 h. The results demonstrated that andrographolide can induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax, caspase-3 and decrease expression of bcl-2 determined by immunohistochemical analysis.

摘要

从穿心莲（爵床科）中分离出的穿心莲内酯，在0.35毫摩尔、0.70毫摩尔和1.40毫摩尔浓度下，对TD-47人乳腺癌细胞系处理24、48和72小时后，可诱导DNA片段化并增加凋亡细胞的百分比。结果表明，穿心莲内酯可通过免疫组织化学分析测定的p53、bax、caspase-3表达增加和bcl-2表达降低，以时间和浓度依赖性方式诱导TD-47人乳腺癌细胞系凋亡。

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本文引用的文献

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Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial.规范化穿心莲提取物治疗普通感冒的对照临床试验——一项初步试验。
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Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata.从穿心莲根部分离出的一些呫吨酮类化合物的抗疟活性。
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DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells.穿心莲内酯新型半合成类似物DRF 3188：对MCF 7乳腺癌细胞的细胞反应
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Anticancer and immunostimulatory compounds from Andrographis paniculata.穿心莲中的抗癌和免疫刺激化合物。
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Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy.穿心莲治疗上呼吸道感染：安全性和有效性的系统评价
Planta Med. 2004 Apr;70(4):293-8. doi: 10.1055/s-2004-818938.
6
Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats.穿心莲内酯对链脲佐菌素诱导的糖尿病大鼠的降血糖作用。
Planta Med. 2003 Dec;69(12):1075-9. doi: 10.1055/s-2003-45185.
7
Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata.穿心莲内酯，一种从穿心莲中分离出的潜在癌症治疗剂。
J Exp Ther Oncol. 2003 May-Jun;3(3):147-58. doi: 10.1046/j.1359-4117.2003.01090.x.
8
Antimicrobial activity of Andrographis paniculata.穿心莲的抗菌活性。
Fitoterapia. 2003 Dec;74(7-8):692-4. doi: 10.1016/s0367-326x(03)00159-x.
9
Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect.穿心莲内酯可抑制人中性粒细胞产生氧自由基：其抗炎作用的可能机制。
Br J Pharmacol. 2002 Jan;135(2):399-406. doi: 10.1038/sj.bjp.0704493.
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Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells.丁酸钠可诱导MCF-7人乳腺癌细胞发生不依赖P53、由Fas介导的凋亡。
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