穿心莲内酯对TD - 47人乳腺癌细胞系的凋亡诱导作用。
Apoptosis inducing effect of andrographolide on TD-47 human breast cancer cell line.
作者信息
Sukardiman Harjotaruno, Widyawaruyanti Aty, Zaini Noor Cholies
机构信息
Department of Natural Product Sciences, Faculty of Pharmacy Airlangga University, Surabaya, Indonesia.
出版信息
Afr J Tradit Complement Altern Med. 2007 Feb 16;4(3):345-51. doi: 10.4314/ajtcam.v4i3.31228.
Abstract
Andrographolide isolated from Andrographis paniculata Ness (Acanthaceae) at 0.35 mM, 0.70 mM and 1.40 mM induced DNA fragmentation and increased the percentage of apoptotic cells when TD-47 human breast cancer cell line was treated for 24, 48 and 72 h. The results demonstrated that andrographolide can induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax, caspase-3 and decrease expression of bcl-2 determined by immunohistochemical analysis.
摘要
从穿心莲（爵床科）中分离出的穿心莲内酯，在0.35毫摩尔、0.70毫摩尔和1.40毫摩尔浓度下，对TD-47人乳腺癌细胞系处理24、48和72小时后，可诱导DNA片段化并增加凋亡细胞的百分比。结果表明，穿心莲内酯可通过免疫组织化学分析测定的p53、bax、caspase-3表达增加和bcl-2表达降低，以时间和浓度依赖性方式诱导TD-47人乳腺癌细胞系凋亡。
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