Gidado Abubakar, Ameh Danladi A, Atawodi Sunday E, Ibrahim Sani
Department of Biochemistry, University of Maiduguri, Maiduguri, Nigeria.
Afr J Tradit Complement Altern Med. 2008 Jan 22;5(2):201-8. doi: 10.4314/ajtcam.v5i2.31274.
Aqueous, ethanolic and hexane extracts of the leaves of Nauclea latifolia (Rubiaceae) were assessed for their fasting blood glucose lowering effect in normoglycaemic and streptozotocin-diabetic rats. Wistar strain albino rats were given different doses of the extracts after 18 hrs fast and their blood glucose measured at 0, 1, 2, 4 and 6 hours after treatment. The aqueous and ethanolic extracts significantly lowered the fasting blood glucose levels of the STZ-diabetic rats in a dose-dependent manner. The highest dose administered (400 mg/kg) lowered the fasting blood glucose of the diabetic rats by 31.7% (aqueous) and 36.1% (ethanolic) extracts. The aqueous extract did not significantly lower the glucose levels of normoglycaemic rats (maximum 6.6%), nor was any significant decrease seen in the rats administered with the hexane (maximum of 4.0% for normoglycaemic and 2.4% for diabetics) extract. The hypoglycaemic and antihyperglycaemic potentials of the aqueous and ethanolic extracts were comparable to that of glibenclamide (1 mg/kg).These results further support the traditional use of the plant in the treatment of diabetes mellitus.
对乌檀（茜草科）叶的水提取物、乙醇提取物和己烷提取物在正常血糖和链脲佐菌素诱导的糖尿病大鼠中降低空腹血糖的作用进行了评估。禁食18小时后的Wistar品系白化大鼠给予不同剂量的提取物，并在治疗后0、1、2、4和6小时测量其血糖。水提取物和乙醇提取物以剂量依赖性方式显著降低了链脲佐菌素诱导的糖尿病大鼠的空腹血糖水平。给予的最高剂量（400mg/kg）使糖尿病大鼠的空腹血糖降低了31.7%（水提取物）和36.1%（乙醇提取物）。水提取物未显著降低正常血糖大鼠的血糖水平（最大降低6.6%），给予己烷提取物的大鼠也未见显著降低（正常血糖大鼠最大降低4.0%，糖尿病大鼠最大降低2.4%）。水提取物和乙醇提取物的降血糖和抗高血糖潜力与格列本脲（1mg/kg）相当。这些结果进一步支持了该植物在治疗糖尿病方面的传统用途。
