积雪草对人乳腺癌细胞的凋亡诱导作用。
Apoptosis induction of Centella asiatica on human breast cancer cells.
作者信息
Babykutty Suboj, Padikkala Jose, Sathiadevan Priya Prasanna, Vijayakurup Vinod, Azis Thasni Karedath Abdul, Srinivas Priya, Gopala Srinivas
机构信息
Department of Biochemistry, Sree Chitra Tirunal Institute for Medial Sciences and Technology, Thiruvananthapuram 695011, Kerala, India.
出版信息
Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):9-16. doi: 10.4314/ajtcam.v6i1.57068.
Abstract
The present study evaluated the ability of methanolic extract of Centella asiatica (Linn) Urban (Umbelliferae) to induce apoptosis in different cancer cell lines. MCF-7 cells emerged as the most sensitive cell line for in vitro growth inhibitory activity. C. asiatica extract induced apoptosis in MCF-7 cells as indicated by nuclear condensation, increased annexin staining, loss of mitochondrial membrane potential and induction of DNA breaks identified by TUNEL reactivity. It is possible that the use of C. asiatica extract as a component in herbal medicines could be justifiable.
摘要
本研究评估了积雪草（伞形科）甲醇提取物诱导不同癌细胞系凋亡的能力。MCF-7细胞成为体外生长抑制活性最敏感的细胞系。积雪草提取物诱导MCF-7细胞凋亡，表现为核浓缩、膜联蛋白染色增加、线粒体膜电位丧失以及通过TUNEL反应鉴定的DNA断裂。将积雪草提取物用作草药的一种成分可能是合理的。
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