对坦桑尼亚一些传统上用于治疗真菌感染的植物进行卤虫毒性评估。
Brine shrimp toxicity evaluation of some Tanzanian plants used traditionally for the treatment of fungal infections.
作者信息
Moshi Mainen J, van den Beukel Carolien J P, Hamza Omar J M, Mbwambo Zakaria H, Nondo Ramadhani O S, Masimba Pax J, Matee Mecky I N, Kapingu Modest C, Mikx Frans, Verweij Paul E, van der Ven André J A M
机构信息
Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.
出版信息
Afr J Tradit Complement Altern Med. 2006 Nov 13;4(2):219-25. doi: 10.4314/ajtcam.v4i2.31211.
Plants which are used by traditional healers in Tanzania have been evaluated to obtain preliminary data of their toxicity using the brine shrimps test. The results indicate that 9 out of 44 plant species whose extracts were tested exhibited high toxicity with LC(50) values below 20 microg/ml. These include Aloe lateritia Engl. (Aloaceae) [19.1 microg/ml], Cassia abbreviata Oliv. (Caesalpiniaceae) [12.7 microg/ml], Croton scheffleri Pax (Euphorbiaceae) [13.7 microg/ml], Hymenodactyon parvifolium Brig (Rubiaceae) [13.4 microg/ml], Kigelia Africana L. (Bignoniaceae) [7.2 microg/ml], and Ocimum suave Oliv. (Labiatae) [16.7 microg/ml]. Twelve plants gave LC(50) values between 21 and 50 microg/ml, 11 plants gave LC(50) values between 50 and 100 microg/ml, and 18 plants gave LC(50) values greater than 100 microg/ml.
坦桑尼亚传统治疗师使用的植物已通过卤虫试验进行评估，以获取其毒性的初步数据。结果表明，在测试提取物的44种植物物种中，有9种表现出高毒性，其半数致死浓度（LC(50)）值低于20微克/毫升。这些植物包括迟花芦荟（Aloe lateritia Engl.，芦荟科）[19.1微克/毫升]、短叶决明（Cassia abbreviata Oliv.，苏木科）[12.7微克/毫升]、舍氏巴豆（Croton scheffleri Pax，大戟科）[13.7微克/毫升]、小叶膜萼花（Hymenodactyon parvifolium Brig，茜草科）[13.4微克/毫升]、非洲吊灯树（Kigelia Africana L.，紫葳科）[7.2微克/毫升]和柔细罗勒（Ocimum suave Oliv.，唇形科）[16.7微克/毫升]。12种植物的LC(50)值在21至50微克/毫升之间，11种植物的LC(50)值在50至100微克/毫升之间，18种植物的LC(50)值大于100微克/毫升。
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