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心房扑动/颤动患者与对照组红细胞膜中的脂肪酸百分比。

Fatty acid percentage in erythrocyte membranes of atrial flutter/fibrillation patients and controls.

作者信息

Viviani Anselmi Chiara, Ferreri Carla, Novelli Valeria, Roncarati Roberta, Bronzini Roberta, Marchese Giovanni, Somalvico Francesco, Condorelli Gianluigi, Montenero Annibale Sandro, Puca Annibale Alessandro

机构信息

Istituto Ricovero Cura Carattere Scientifico Multimedica, Milan, Italy.

出版信息

J Interv Card Electrophysiol. 2010 Mar;27(2):95-9. doi: 10.1007/s10840-009-9466-8. Epub 2010 Feb 17.

DOI:10.1007/s10840-009-9466-8
PMID:20162444
Abstract

PURPOSE

Several epidemiological published data support the protective role of omega-3 consumption in coronary artery disease, sudden cardiac death and ventricular arrhythmias, but interestingly, this is not the case for atrial arrhythmias. The purpose of this study is to evaluate different fatty acid profile between AF/AFL subjects and healthy controls.

METHODS

Gas chromatography was employed to determine fatty acid percentage of erythrocyte membranes from 40 idiopathic AFL/AF patients and 53 healthy control subjects.

RESULTS

AFL/AF erythrocyte membranes had significantly lower percentage of saturated fatty acid (43.1 +/- SD2.2 versus 47.8 +/- SD9.6, p < 0.001), monounsaturated fatty acid (18.2 +/- SD2.5 versus 22.6 +/- SD5.2, p < 0.001) and total trans fatty acid (0.2 +/- SD0.1 vs 1.3 +/- SD1.1, p < 0.001) than controls. Furthermore, fatty acid (FA) profiles of arrhythmic individuals showed an increased percent of total polyunsaturated fatty acid (PUFA) (36.7 +/- SD2.4 versus 26.4 +/- SD10.4, p < 0.001), PUFA n-3 (5.3 +/- SD1.1 versus 2.8 +/- SD1.8, p < 0.001) and n-6 (31.4 +/- SD2.2 versus 23.5 +/- SD9.9, p < 0.001).

CONCLUSION

This study shows that the erythrocyte membranes FA composition of AF/AFL subjects differs from that of healthy controls.

摘要

目的

多项已发表的流行病学数据支持摄入ω-3对冠状动脉疾病、心源性猝死和室性心律失常具有保护作用，但有趣的是，对房性心律失常并非如此。本研究的目的是评估房颤/房扑患者与健康对照者之间不同的脂肪酸谱。

方法

采用气相色谱法测定40例特发性房扑/房颤患者和53例健康对照者红细胞膜中的脂肪酸百分比。

结果

与对照组相比，房扑/房颤患者的红细胞膜中饱和脂肪酸（43.1±标准差2.2对47.8±标准差9.6，p<0.001）、单不饱和脂肪酸（18.2±标准差2.5对22.6±标准差5.2，p<0.001）和总反式脂肪酸（0.2±标准差0.1对1.3±标准差1.1，p<0.001）的百分比显著降低。此外，心律失常患者的脂肪酸（FA）谱显示总多不饱和脂肪酸（PUFA）（36.7±标准差2.4对26.4±标准差10.4，p<0.001）、PUFA n-3（5.3±标准差1.1对2.8±标准差1.8，p<0.001）和n-6（31.4±标准差2.2对23.5±标准差9.9，p<0.001）的百分比增加。

结论

本研究表明，房颤/房扑患者的红细胞膜脂肪酸组成与健康对照者不同。

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