迈向对磁场进行动态控制，以将磁性载体聚焦到身体内部深处的目标部位。
Towards dynamic control of magnetic fields to focus magnetic carriers to targets deep inside the body.
作者信息
Shapiro Benjamin
机构信息
Bio-Engineering/Aerospace Engineering, 3178 Martin Hall, University of Maryland at College Park, College Park, MD 20742, USA.
出版信息
J Magn Magn Mater. 2009 May 1;321(10):1594. doi: 10.1016/j.jmmm.2009.02.094.
Abstract
Magnetic drug delivery has the potential to target therapy to specific regions in the body, improving efficacy and reducing side effects for treatment of cancer, stroke, infection, and other diseases. Using stationary external magnets, which attract the magnetic drug carriers, this treatment is limited to shallow targets (<5 cm below skin depth using the strongest possible, still safe, practical magnetic fields). We consider dynamic magnetic actuation and present initial results that show it is possible to vary magnets one against the other to focus carriers between them on average. The many remaining tasks for deep targeting in-vivo are then briefly noted.
摘要
磁性药物递送有潜力将治疗靶向身体的特定区域，提高癌症、中风、感染和其他疾病治疗的疗效并减少副作用。使用固定的外部磁体来吸引磁性药物载体，这种治疗仅限于浅层靶点（在使用尽可能强但仍安全、实用的磁场时，皮肤深度以下<5厘米）。我们考虑了动态磁驱动，并展示了初步结果，结果表明可以使磁体相互变化，从而平均地将载体聚焦在它们之间。然后简要指出了在体内进行深度靶向的许多剩余任务。
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